CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. (Q36399104)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15184500%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

title

CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15184500%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference

1

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29 December 2019

5

Ralph M Steinman

1 reference

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29 December 2019

3

Kara Olson

1 reference

29 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15184500%20AND%20SRC:MED&resulttype=core&format=json

4

Priscilla Toy

1 reference

29 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15184500%20AND%20SRC:MED&resulttype=core&format=json

Sayuri Yamazaki

2

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29 December 2019

publication date

1 June 2004

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15184500%20AND%20SRC:MED&resulttype=core&format=json

Journal of Experimental Medicine

29 December 2019

language of work or name

English

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published in

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29 December 2019

volume

199

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29 December 2019

issue

11

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29 December 2019

page(s)

1467-1477

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Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

29 December 2019

cites work

1 reference

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Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.

30 September 2017

1 reference

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CD4+ CD25+ regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo

30 September 2017

1 reference

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Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo

30 September 2017

1 reference

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Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells

30 September 2017

1 reference

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In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro

30 September 2017

1 reference

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Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

30 September 2017

1 reference

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Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells

30 September 2017

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

30 September 2017

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

30 September 2017

1 reference

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Control of regulatory T cell development by the transcription factor Foxp3

30 September 2017

1 reference

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CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms

30 September 2017

1 reference

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Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice

30 September 2017

1 reference

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CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer

30 September 2017

1 reference

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Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease

30 September 2017

1 reference

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Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice.

30 September 2017

1 reference

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The enemy within: keeping self-reactive T cells at bay in the periphery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Multiple immuno-regulatory defects in type-1 diabetes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor

30 September 2017

1 reference

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Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

30 September 2017

1 reference

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X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Insulin-dependent diabetes mellitus and its animal models.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes

30 September 2017

1 reference

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CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

30 September 2017

1 reference

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Spontaneous Autoimmune Diabetes in Monoclonal T Cell Nonobese Diabetic Mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

T-cell responses to autoantigens in IDDM. The search for the Holy Grail

30 September 2017

1 reference

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Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Checkpoints in the progression of autoimmune disease: lessons from diabetes models

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Breeding of a non-obese, diabetic strain of mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Cell-intrinsic effects of non-MHC NOD genes on dendritic cell generation in vivo

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211787

T-cell compartments of prediabetic NOD mice

21 September 2018

1 reference

12 December 2020

Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development

1 reference

12 December 2020

Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors

1 reference

12 December 2020

Following a diabetogenic T cell from genesis through pathogenesis

1 reference

12 December 2020

Insulin-dependent diabetes mellitus

1 reference

12 December 2020

Number of autoantibodies (against insulin, GAD or ICA512/IA2) rather than particular autoantibody specificities determines risk of type I diabetes

1 reference

12 December 2020

Cellular and molecular changes accompanying the progression from insulitis to diabetes

1 reference

12 December 2020

Phenotypic and Functional Characteristics of BM-Derived DC from NOD and Non-Diabetes-Prone Strains

1 reference

12 December 2020

CD4+CD25+ T-cell development is regulated by at least 2 distinct mechanisms

1 reference

12 December 2020

Intrinsic in vitro abnormalities in dendritic cell generation caused by non-MHC non-obese diabetic genes

1 reference

12 December 2020

The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20040180

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15184500%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15184500%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

15184500

1 reference