Signals and pathways controlling regulatory T cells (Q38187171)

30 August 2017

Signals and pathways controlling regulatory T cells (English)

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30 August 2017

Alexandria Huynh

1

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30 August 2017

Ruan Zhang

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2

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30 August 2017

Laurence A Turka

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3

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30 August 2017

language of work or name

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1 March 2014

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30 August 2017

Immunological Reviews

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30 August 2017

258

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30 August 2017

117-131

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30 August 2017

1

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

30 August 2017

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Control of regulatory T cell development by the transcription factor Foxp3

21 January 2018

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Mechanisms maintaining enhancement of allografts. I. Demonstration of a specific suppressor cell

21 January 2018

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Identification of regulatory T cells in tolerated allografts

21 January 2018

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Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance

21 January 2018

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Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation

21 January 2018

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Promises and obstacles for the blockade of CD40-CD40L interactions in allotransplantation.

21 January 2018

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Messenger RNA for FOXP3 in the urine of renal-allograft recipients

21 January 2018

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Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

21 January 2018

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Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients

21 January 2018

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Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo.

21 January 2018

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Rapamycin does not induce anergy but inhibits expansion and differentiation of alloreactive human T cells

21 January 2018

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Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin

21 January 2018

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Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells

21 January 2018

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FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

21 January 2018

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Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells

21 January 2018

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Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

21 January 2018

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Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

21 January 2018

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Developmental regulation of Foxp3 expression during ontogeny.

21 January 2018

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Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells

21 January 2018

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CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

21 January 2018

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Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice.

21 January 2018

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LAT-mediated signaling in CD4+CD25+ regulatory T cell development

21 January 2018

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The importance of LAT in the activation, homeostasis, and regulatory function of T cells

21 January 2018

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The role of the LAT-PLC-gamma1 interaction in T regulatory cell function

21 January 2018

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Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

21 January 2018

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A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity

21 January 2018

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Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function.

21 January 2018

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Differential requirement of PKC-theta in the development and function of natural regulatory T cells

21 January 2018

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Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation

21 January 2018

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Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery

21 January 2018

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CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells

21 January 2018

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c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells

21 January 2018

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Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function

21 January 2018

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Mature T cells depend on signaling through the IKK complex.

21 January 2018

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An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

21 January 2018

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T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

21 January 2018

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CD4⁺CD25⁺Foxp3⁺ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion

21 January 2018

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T cell receptor CDR3 sequence but not recognition characteristics distinguish autoreactive effector and Foxp3(+) regulatory T cells

21 January 2018

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Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.

21 January 2018

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Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo

21 January 2018

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Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.

21 January 2018

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Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking

21 January 2018

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Antigen-specific peripheral shaping of the natural regulatory T cell population

21 January 2018

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Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen

21 January 2018

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TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

21 January 2018

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High TCR stimuli prevent induced regulatory T cell differentiation in a NF-κB-dependent manner

21 January 2018

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Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint

21 January 2018

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Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28

21 January 2018

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Impaired negative selection in CD28-deficient mice.

21 January 2018

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Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes

21 January 2018

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A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.

21 January 2018

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

21 January 2018

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Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

21 January 2018

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CD28 signaling in T regulatory precursors requires p56lck and rafts integrity to stabilize the Foxp3 message

21 January 2018

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Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development.

21 January 2018

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c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells

21 January 2018

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Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

21 January 2018

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CD28 facilitates the generation of Foxp3(-) cytokine responsive regulatory T cell precursors.

21 January 2018

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B7/CD28 in central tolerance: costimulation promotes maturation of regulatory T cell precursors and prevents their clonal deletion

21 January 2018

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The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens

21 January 2018

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Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis

21 January 2018

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Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus

21 January 2018

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Effective proliferation of human regulatory T cells requires a strong costimulatory CD28 signal that cannot be substituted by IL-2.

21 January 2018

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CD28 costimulation is essential for human T regulatory expansion and function

21 January 2018

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Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

21 January 2018

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Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

21 January 2018

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Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment

21 January 2018

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Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period

21 January 2018

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Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

21 January 2018

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Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

21 January 2018

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A function for interleukin 2 in Foxp3-expressing regulatory T cells

21 January 2018

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Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.

21 January 2018

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A two-step process for thymic regulatory T cell development.

21 January 2018

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IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

21 January 2018

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

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Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells

21 January 2018

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A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells

21 January 2018

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Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

21 January 2018

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Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

21 January 2018

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Selective stimulation of T cell subsets with antibody-cytokine immune complexes.

21 January 2018

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Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

21 January 2018

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In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

21 January 2018

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Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells

21 January 2018

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Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene.

21 January 2018

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Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.

21 January 2018

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Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity

21 January 2018

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IL2RA/CD25 polymorphisms contribute to multiple sclerosis susceptibility.

21 January 2018

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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

21 January 2018

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Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases

21 January 2018

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

21 January 2018

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The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

21 January 2018

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Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice

21 January 2018

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Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.

21 January 2018

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Novel Foxo1-dependent transcriptional programs control T(reg) cell function

21 January 2018

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T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

21 January 2018

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

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Phosphorylation and activation of p70s6k by PDK1

21 January 2018

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Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

21 January 2018

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

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Systemic elevation of PTEN induces a tumor-suppressive metabolic state

21 January 2018

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Foxo transcription factors control regulatory T cell development and function

21 January 2018

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Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells

21 January 2018

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The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

21 January 2018

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mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function

21 January 2018

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SHIP deficiency causes Crohn's disease-like ileitis

21 January 2018

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Lineage extrinsic and intrinsic control of immunoregulatory cell numbers by SHIP.

21 January 2018

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SHIP limits immunoregulatory capacity in the T-cell compartment.

21 January 2018

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SHIP regulates the reciprocal development of T regulatory and Th17 cells

21 January 2018

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T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses

21 January 2018

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Lipid phosphatases identified by screening a mouse phosphatase shRNA library regulate T-cell differentiation and protein kinase B AKT signaling.

21 January 2018

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Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

21 January 2018

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Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

21 January 2018

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21 January 2018

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Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease

21 January 2018

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An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness.

21 January 2018

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Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses

21 January 2018

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Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways

21 January 2018

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The CD28 signaling pathway regulates glucose metabolism

21 January 2018

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Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.

21 January 2018

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

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Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice

21 January 2018

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Dichloroacetate at therapeutic concentration alters glucose metabolism and induces regulatory T-cell differentiation in alloreactive human lymphocytes

21 January 2018

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HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

21 January 2018

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

21 January 2018

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

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The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene.

21 January 2018

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Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense

21 January 2018

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Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

21 January 2018

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Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

21 January 2018

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Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells.

21 January 2018

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PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

21 January 2018

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Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

21 January 2018

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Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

21 January 2018

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Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

21 January 2018

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FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase

21 January 2018

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The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.

21 January 2018

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The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity

21 January 2018

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FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.

21 January 2018

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Stability of the regulatory T cell lineage in vivo.

21 January 2018

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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

21 January 2018

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Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.

21 January 2018

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Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth

21 January 2018

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Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells

21 January 2018

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Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

21 January 2018

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DNA methylation controls Foxp3 gene expression

21 January 2018

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DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.

21 January 2018

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Epigenetic control of the foxp3 locus in regulatory T cells

21 January 2018

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Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation

21 January 2018

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Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

21 January 2018

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Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist

21 January 2018

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T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

21 January 2018

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Early events in the thymus affect the balance of effector and regulatory T cells

21 January 2018

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Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

21 January 2018

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Influence of SHIP on the NK Repertoire and Allogeneic Bone Marrow Transplantation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IMR.12148

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30 August 2017

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