Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death (Q28217736)

Europe PubMed Central

title

Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death (English)

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R Sattler

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M Tymianski

series ordinal

2

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language of work or name

English

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publication date

2001

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Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus

published in

Molecular Neurobiology

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volume

24

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page(s)

107-29

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issue

1-3

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cites work

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12 December 2020

Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice

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Differential antagonism of alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid-preferring and kainate-preferring receptors by 2,3-benzodiazepines

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Regulation of kinetic and pharmacological properties of synaptic NMDA receptors depends on presynaptic exocytosis in rat hippocampal neurones.

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Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS

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Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate

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Role of NMDA receptor functional domains in excitatory cell death

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Zn(2+): a novel ionic mediator of neural injury in brain disease.

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A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade.

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Glutamate receptors put in their place

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Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus

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Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits

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Kainate receptors: subunits, synaptic localization and function

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NSF binding to GluR2 regulates synaptic transmission

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Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

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12 December 2020

The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and function

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12 December 2020

Functional evaluation of glutamate receptor subtypes in cultured cerebellar neurones and astrocytes

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12 December 2020

Structure and regulation of voltage-gated Ca2+ channels

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Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease

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12 December 2020

Organization and regulation of proteins at synapses

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12 December 2020

Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways.

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12 December 2020

Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains

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12 December 2020

Ligand-gated ion channel interactions with cytoskeletal and signaling proteins

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12 December 2020

The distribution of splice variants of the NMDAR1 subunit mRNA in adult rat brain

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12 December 2020

Agonist-activated cobalt uptake identifies divalent cation-permeable kainate receptors on neurons and glial cells

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12 December 2020

Relative concentrations and seizure-induced changes in mRNAs encoding three AMPA receptor subunits in hippocampus and cortex

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12 December 2020

Evidence for the GluR6 gene associated with younger onset age of Huntington's disease

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12 December 2020

Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo

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12 December 2020

Alternative splicing of the C-terminal domain regulates cell surface expression of the NMDA receptor NR1 subunit

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12 December 2020

Functional NMDA receptors are transiently active and support the survival of Purkinje cells in culture.

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12 December 2020

Glutamate neurotoxicity and Huntington's chorea

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12 December 2020

Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptor channels

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12 December 2020

Developmental expression of NMDA receptor subunits and the emergence of glutamate neurotoxicity in primary cultures of murine cerebral cortical neurons.

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12 December 2020

Spine loss and other persistent alterations of hippocampal pyramidal cell dendrites in a model of early-onset epilepsy.

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12 December 2020

Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity

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12 December 2020

A direct comparison of the single-channel properties of synaptic and extrasynaptic NMDA receptors.

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12 December 2020

The toxic effect of sodium L-glutamate on the inner layers of the retina.

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12 December 2020

Phenotypic down-regulation of glutamate receptor subunit GluR1 in Alzheimer's disease

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12 December 2020

Activity-dependent regulation of N-methyl-D-aspartate receptor subunit expression in rat cerebellar granule cells.

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12 December 2020

Mediation of neuronal apoptosis by enhancement of outward potassium current.

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12 December 2020

SAP90 binds and clusters kainate receptors causing incomplete desensitization

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12 December 2020

Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein

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12 December 2020

Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death

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12 December 2020

PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands

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12 December 2020

Ionic dependence of glutamate neurotoxicity

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12 December 2020

Nitric oxide signaling in the nervous system

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12 December 2020

Reflections on Ca(2+)-channel diversity, 1988-1994.

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12 December 2020

Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines.

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12 December 2020

GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex

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12 December 2020

Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit.

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12 December 2020

Human GluR6 kainate receptor (GRIK2): molecular cloning, expression, polymorphism, and chromosomal assignment

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12 December 2020

Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins.

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12 December 2020

Competitive binding of alpha-actinin and calmodulin to the NMDA receptor

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12 December 2020

Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

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12 December 2020

Q/R editing of the rat GluR5 and GluR6 kainate receptors in vivo and in vitro: evidence for independent developmental, pathological and cellular regulation

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12 December 2020

Enhanced LTP in mice deficient in the AMPA receptor GluR2.

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12 December 2020

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A

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12 December 2020

Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

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12 December 2020

Axonal injury alters alternative splicing of the retinal NR1 receptor: the preferential expression of the NR1b isoforms is crucial for retinal ganglion cell survival

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12 December 2020

Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus

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12 December 2020

Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice

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12 December 2020

Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism.

1 reference

12 December 2020

Assembly of proteins to postsynaptic densities after transient cerebral ischemia.

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12 December 2020

Synaptic activity mediates death of hypoxic neurons

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12 December 2020

Calcium signaling in neurons: molecular mechanisms and cellular consequences

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12 December 2020

Ca2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR6

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12 December 2020

The influence of glutamate receptor 2 expression on excitotoxicity in Glur2 null mutant mice.

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12 December 2020

Calmodulin mediates calcium-dependent inactivation of N-methyl-D-aspartate receptors

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12 December 2020

Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions.

1 reference

12 December 2020

Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis.

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12 December 2020

Functional change of NMDA receptors related to enhancement of susceptibility to neurotoxicity in the developing pontine nucleus.

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12 December 2020

Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule

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12 December 2020

Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors

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12 December 2020

Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity.

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12 December 2020

Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA.

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12 December 2020

Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments.

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12 December 2020

Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia

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12 December 2020

Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury

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12 December 2020

High actin concentrations in brain dendritic spines and postsynaptic densities

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12 December 2020

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

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12 December 2020

Emergence of excitotoxicity in cultured forebrain neurons coincides with larger glutamate-stimulated [Ca(2+)](i) increases and NMDA receptor mRNA levels

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12 December 2020

Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways

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12 December 2020

Organization of N-methyl-D-aspartate glutamate receptor gene expression in the basal ganglia of the rat.

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12 December 2020

Selective up-regulation of an NMDA receptor subunit mRNA in cultured cerebellar granule cells by K(+)-induced depolarization and NMDA treatment.

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12 December 2020

Mice with reduced NMDA receptor expression display behaviors related to schizophrenia

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12 December 2020

Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor

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12 December 2020

AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability

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12 December 2020

Attenuation of focal cerebral infarct in mice lacking NMDA receptor subunit NR2C

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12 December 2020

Evidence for a tetrameric structure of recombinant NMDA receptors.

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12 December 2020

Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1

1 reference

12 December 2020

Alteration of Ca2+ permeability and sensitivity to Mg2+ and channel blockers by a single amino acid substitution in the N-methyl-D-aspartate receptor.

1 reference

12 December 2020

Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: differential attachment of NMDA versus AMPA receptors.

1 reference

12 December 2020

Glutamate neurotoxicity in cortical cell culture.

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12 December 2020

Generation and analysis of GluR5(Q636R) kainate receptor mutant mice

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12 December 2020

Modification of postsynaptic densities after transient cerebral ischemia: a quantitative and three-dimensional ultrastructural study.

1 reference

12 December 2020

Presynaptic exocytosis regulates NR2A mRNA expression in cultured neocortical neurones.

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12 December 2020

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

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12 December 2020

Altered interaction between PSD-95 and the NMDA receptor following transient global ischemia

1 reference

12 December 2020

Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+-dependent inactivation of NMDA receptors

1 reference

12 December 2020

Role of the carboxy-terminal region of the GluR epsilon2 subunit in synaptic localization of the NMDA receptor channel

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12 December 2020

Seizure-induced neuronal death is associated with induction of c-Jun N-terminal kinase and is dependent on genetic background.

1 reference

12 December 2020

PDZ domains: targeting signalling molecules to sub-membranous sites

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12 December 2020

Cytosolic calcium concentrations and cell death in vitro.

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12 December 2020

Glutamate-operated channels: developmentally early and mature forms arise by alternative splicing.

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12 December 2020

Postsynaptic organization and regulation of excitatory synapses

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12 December 2020

Modulation of the channel activity of the epsilon2/zeta1-subtype N-methyl D-aspartate receptor by PSD-95.

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12 December 2020

Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor

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12 December 2020

Calcium transport and buffering in neurons

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12 December 2020

Sublethal oxygen-glucose deprivation alters hippocampal neuronal AMPA receptor expression and vulnerability to kainate-induced death.

1 reference

12 December 2020

PDZ domains in synapse assembly and signalling

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12 December 2020

Presynaptic kainate receptors in the monkey striatum

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12 December 2020

Glutamate neurotoxicity and diseases of the nervous system

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12 December 2020

RNA editing of brain glutamate receptor channels: mechanism and physiology

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12 December 2020

Glutamate as a neurotransmitter in the brain: review of physiology and pathology

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12 December 2020

Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor

1 reference

12 December 2020

Molecular mechanisms of calcium-dependent excitotoxicity

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12 December 2020

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

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12 December 2020

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12 December 2020

Calcium directly permeates kainate/alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptors in cultured cerebellar Purkinje neurons

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12 December 2020

Changes in gene expression of AMPA-selective glutamate receptor subunits induced by status epilepticus in rat brain

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12 December 2020

Rapid, activation-induced redistribution of ionotropic glutamate receptors in cultured hippocampal neurons.

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12 December 2020

Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats

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12 December 2020

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

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12 December 2020

Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons

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12 December 2020

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum

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12 December 2020

N-methyl-D-aspartate promotes the survival of cerebellar granule cells in culture

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12 December 2020

A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II

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12 December 2020

Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate.

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12 December 2020

Global ischemia induces downregulation of Glur2 mRNA and increases AMPA receptor-mediated Ca2+ influx in hippocampal CA1 neurons of gerbil

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12 December 2020

Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors.

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12 December 2020

Characterization of excitatory amino acid neurotoxicity in N-methyl-D-aspartate receptor-deficient mouse cortical neuronal cells

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12 December 2020

SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family

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12 December 2020

Identification of a site in glutamate receptor subunits that controls calcium permeability

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12 December 2020

Differences in Ca2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression.

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12 December 2020

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

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12 December 2020

Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95

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12 December 2020

Vulnerability of CA1 neurons to glutamate is developmentally regulated.

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12 December 2020

Modeling buffered Ca2+ diffusion near the membrane: implications for secretion in neuroendocrine cells

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12 December 2020

Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

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12 December 2020

Enlightening the postsynaptic density

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12 December 2020

Heteromeric NMDA receptors: molecular and functional distinction of subtypes

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12 December 2020

Regulation of F-actin stability in dendritic spines by glutamate receptors and calcineurin.

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12 December 2020

RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency

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12 December 2020

Dysfunctions in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R)

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12 December 2020

Calcium-dependent inactivation of synaptic NMDA receptors in hippocampal neurons

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12 December 2020

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12 December 2020

Isoform specificity in the relationship of actin to dendritic spines.

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12 December 2020

The synaptic activation of kainate receptors.

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12 December 2020

PDZ domain of neuronal nitric oxide synthase recognizes novel C-terminal peptide sequences

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12 December 2020

NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins.

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12 December 2020

Cloned glutamate receptors

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12 December 2020

Ca2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells.

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12 December 2020

Glutamate-induced increase in intracellular Ca2+ in cerebral cortex neurons is transient in immature cells but permanent in mature cells

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12 December 2020

Fate of the hippocampal mossy fiber projection after destruction of its postsynaptic targets with intraventricular kainic acid

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12 December 2020

Unchanged balance between levels of mRNA encoding AMPA glutamate receptor subtypes following global cerebral ischemia in the rat

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12 December 2020

Pharmacology of AMPA antagonists and their role in neuroprotection

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12 December 2020

The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs

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12 December 2020

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit

1 reference

12 December 2020

Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy

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12 December 2020

The role of RNA editing of kainate receptors in synaptic plasticity and seizures

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12 December 2020

C-Terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors

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12 December 2020

Kainate receptor subunits expressed in single cultured hippocampal neurons: molecular and functional variants by RNA editing.

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12 December 2020

The AMPAR subunit GluR2: still front and center-stage

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12 December 2020

Activity regulates the synaptic localization of the NMDA receptor in hippocampal neurons.

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12 December 2020

Molecular diversity of the NMDA receptor channel

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12 December 2020

Regulated subcellular distribution of the NR1 subunit of the NMDA receptor

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12 December 2020

Molecular mechanisms of glutamate receptor clustering at excitatory synapses.

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12 December 2020

Overexpression of GluR6 in rat hippocampus produces seizures and spontaneous nonsynaptic bursting in vitro

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12 December 2020

Combinations of AMPA receptor subunit expression in individual cortical neurons correlate with expression of specific calcium-binding proteins.

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12 December 2020

Functional kainate-selective glutamate receptors in cultured hippocampal neurons.

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12 December 2020

Increased thresholds for long-term potentiation and contextual learning in mice lacking the NMDA-type glutamate receptor epsilon1 subunit

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12 December 2020

Ca2+-Zn2+ permeable AMPA or kainate receptors: possible key factors in selective neurodegeneration

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12 December 2020

Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitro

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12 December 2020

Mice with genetically modified NMDA and AMPA receptors.

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12 December 2020

LTP mechanisms: from silence to four-lane traffic

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12 December 2020

Development of intracellular calcium responses to depolarization and to kainate and in cultured mouse hippocampal neurons

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12 December 2020

Knockdown of AMPA receptor GluR2 expression causes delayed neurodegeneration and increases damage by sublethal ischemia in hippocampal CA1 and CA3 neurons

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12 December 2020

Transfection of N-methyl-D-aspartate receptors in a nonneuronal cell line leads to cell death

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12 December 2020

Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B.

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12 December 2020

The contributions of GluR2 to allosteric modulation of AMPA receptors.

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12 December 2020

Protein kinase C modulation of recombinant NMDA receptor currents: roles for the C-terminal C1 exon and calcium ions.

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12 December 2020

Altered association of protein tyrosine kinases with postsynaptic densities after transient cerebral ischemia in the rat brain

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12 December 2020

PDZ Domain Suppression of an ER Retention Signal in NMDA Receptor NR1 Splice Variants

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12 December 2020

Normal and abnormal calcium homeostasis in neurons: a basis for the pathophysiology of traumatic and ischemic central nervous system injury

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12 December 2020

Does neuroprotection improve stroke outcome?

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12 December 2020

Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit

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12 December 2020

Coupling of permeation and gating in an NMDA-channel pore mutant.

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12 December 2020

Alternatively spliced isoforms of the NMDARI receptor subunit

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12 December 2020

Kainate receptors are involved in synaptic plasticity

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12 December 2020

Cortical neurones exhibiting kainate-activated Co2+ uptake are selectively vulnerable to AMPA/kainate receptor-mediated toxicity

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12 December 2020

Cyclic GMP and cell death in rat cerebellar slices.

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12 December 2020

In vivo toxicity of prion protein in murine scrapie: ultrastructural and immunogold studies.

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12 December 2020

Determinants of Ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing

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12 December 2020