Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope (Q33937758)

30 July 2017

Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope (English)

1 reference

30 July 2017

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1 reference

4

Harald von Boehmer

1 reference

30 July 2017

2

Benno Weigmann

1 reference

30 July 2017

1

Carolin Daniel

1 reference

30 July 2017

Roderick Bronson

3

1 reference

PubMed ID

21690251

30 July 2017

language of work or name

English

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publication date

20 June 2011

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Journal of Experimental Medicine

30 July 2017

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30 July 2017

208

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30 July 2017

7

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30 July 2017

1501-1510

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T cell receptor recognition of self and foreign antigens in the induction of autoimmunity

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Antigen-specific induction of regulatory T cells in vivo and in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Stability of the regulatory T cell lineage in vivo.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Enhancement of antigen-specific Treg vaccination in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Murine high specificity/sensitivity competitive europium insulin autoantibody assay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

In vivo instruction of suppressor commitment in naive T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Structural basis of T cell recognition

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Conditions that induce tolerance in mature CD4+ T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Intranasal administration of insulin peptide B: 9-23 protects NOD mice from diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide

5 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110574

Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110574

Low avidity recognition of self-antigen by T cells permits escape from central tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110574

DNA methylation controls Foxp3 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110574

Murine pancreatic islet isolation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135372

Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

29 October 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110574

Evidence that a peptide spanning the B-C junction of proinsulin is an early Autoantigen epitope in the pathogenesis of type 1 diabetes

21 January 2018

1 reference

12 December 2020

Nasal administration of CTB-insulin induces active tolerance against autoimmune diabetes in non-obese diabetic (NOD) mice

1 reference

12 December 2020

Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

1 reference

12 December 2020

Ontogeny of islet cell antibodies, insulin autoantibodies and insulitis in the non-obese diabetic mouse

1 reference

12 December 2020

Insulin autoantibodies in non-obese diabetic (NOD) mice

1 reference

12 December 2020

Life-table analysis of progression to diabetes of anti-insulin autoantibody-positive relatives of individuals with type I diabetes

1 reference

12 December 2020

An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction

1 reference

12 December 2020

Insulin-dependent diabetes mellitus

1 reference

12 December 2020

Inducing and expanding regulatory T cell populations by foreign antigen

1 reference

12 December 2020

Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout

1 reference

12 December 2020

A protocol for islet isolation from mouse pancreas

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20110574

1 reference

30 July 2017

1 reference

30 July 2017

1 reference

PubMed ID

21690251