A role for rebinding in rapid and reliable T cell responses to antigen (Q30946361)

20 August 2017

A role for rebinding in rapid and reliable T cell responses to antigen (English)

1 reference

20 August 2017

Daniel Coombs

3

0 references

Omer Dushek

series ordinal

1

object named as

Omer Dushek

1 reference

20 August 2017

Raibatak Das

2

1 reference

20 August 2017

26 November 2009

1 reference

PLOS Computational Biology

20 August 2017

1 reference

20 August 2017

5

1 reference

20 August 2017

e1000578

1 reference

20 August 2017

11

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Creative Commons Attribution 4.0 International

20 August 2017

start time

26 November 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Rule-based modeling of biochemical systems with BioNetGen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Increased mobility of major histocompatibility complex I-peptide complexes decreases the sensitivity of antigen recognition

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Stochastic effects and bistability in T cell receptor signaling

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Measuring diffusion and binding kinetics by contact area FRAP.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Signal initiation in T-cell receptor microclusters

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Kinetic evidence for a ligand-binding-induced conformational transition in the T cell receptor

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Quantitative challenges in understanding ligand discrimination by alphabeta T cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Molecular mechanisms involved in T cell receptor triggering

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

A role for "self" in T-cell activation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Analysis of two-dimensional dissociation constant of laterally mobile cell adhesion molecules

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Analysis of peptide/MHC-induced TCR downregulation: deciphering the triggering kinetics.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

The kinetic-segregation model: TCR triggering and beyond

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Understanding specificity and sensitivity of T-cell recognition.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Modeling T cell antigen discrimination based on feedback control of digital ERK responses

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

CD8 kinetically promotes ligand binding to the T-cell antigen receptor.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Stop and go traffic to tune T cell responses

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Cooperative enhancement of specificity in a lattice of T cell receptors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Calculations show substantial serial engagement of T cell receptors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Differential clustering of CD4 and CD3zeta during T cell recognition

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

The immunological synapse: a molecular machine controlling T cell activation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Single-particle tracking: applications to membrane dynamics

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T cell receptor/CD3/zeta complex.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Altered T cell receptor ligands trigger a subset of early T cell signals

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Kinetic proofreading in T-cell receptor signal transduction

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Serial triggering of many T-cell receptors by a few peptide-MHC complexes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Role of diffusion in ligand binding to macromolecules and cell-bound receptors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775163

Direct observation of ligand recognition by T cells.

14 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000578

T cell killing does not require the formation of a stable mature immunological synapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000578

A reliable and safe T cell repertoire based on low-affinity T cell receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000578

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000578

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000578

T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000578

Kinetics of MHC-CD8 interaction at the T cell membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000578

Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000578

B cell ligand discrimination through a spreading and contraction response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000578

Analysis of membrane-localized binding kinetics with FRAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000578

Feedback control of T-cell receptor activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000578

Exact stochastic simulation of coupled chemical reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000578

Incorporating Diffusion in Complex Geometries into Stochastic Chemical Kinetics Simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000578

Erratum: Costimulation and endogenous MHC ligands contribute to T cell recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000578

CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate

21 January 2018

1 reference

12 December 2020

TCR triggering by the pMHC complex: valency, affinity, and dynamics

1 reference

12 December 2020

Activated TCRs remain marked for internalization after dissociation from pMHC

1 reference

12 December 2020

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

1 reference

12 December 2020

Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand

1 reference

12 December 2020

Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

1 reference

12 December 2020

Requirements for stimulating naive CD8+ T cells via signal 1 alone

1 reference

12 December 2020

T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics

1 reference

12 December 2020

10.1371/JOURNAL.PCBI.1000578

Identifiers

DOI

1 reference

journals/ploscb/DushekDC09

20 August 2017

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

20 August 2017

1 reference

PMCID

2775163