Optimal antisense target reducing INS intron 1 retention is adjacent to a parallel G quadruplex (Q33843189)

29 July 2017

Optimal antisense target reducing INS intron 1 retention is adjacent to a parallel G quadruplex (English)

1 reference

29 July 2017

Ashish Dhir

4

0 references

Mark S. Searle

object named as

Mark Searle

6

0 references

Emanuele Buratti

object named as

Emanuele Buratti

5

0 references

author name string

Jana Kralovicova

1

1 reference

29 July 2017

Ana Lages

2

1 reference

29 July 2017

Alpa Patel

3

1 reference

29 July 2017

Igor Vorechovsky

7

1 reference

29 July 2017

language of work or name

English

0 references

publication date

17 June 2014

1 reference

29 July 2017

Nucleic Acids Research

1 reference

29 July 2017

42

1 reference

29 July 2017

12

1 reference

29 July 2017

8161-8173

1 reference

Creative Commons Attribution 3.0 Unported

29 July 2017

start time

4 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Negligible impact of rare autoimmune-locus coding-region variants on missing heritability

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The high kinetic stability of a G-quadruplex limits hnRNP F qRRM3 binding to G-tract RNA.

28 July 2018

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A complex network of factors with overlapping affinities represses splicing through intronic elements

28 July 2018

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Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules

28 July 2018

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G-quadruplexes in RNA biology.

28 July 2018

1 reference

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5'-UTR RNA G-quadruplexes: translation regulation and targeting

28 July 2018

1 reference

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RNA therapeutics: beyond RNA interference and antisense oligonucleotides

28 July 2018

1 reference

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Frequent pathway mutations of splicing machinery in myelodysplasia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

The human insulin mRNA is partly translated via a cap- and eIF4A-independent mechanism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Interaction of hnRNPA1/A2 and DAZAP1 with an Alu-derived intronic splicing enhancer regulates ATM aberrant splicing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

The application of DNA and RNA G-quadruplexes to therapeutic medicines.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Quantitative evaluation of all hexamers as exonic splicing elements

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Compensatory signals associated with the activation of human GC 5' splice sites

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Therapeutic approaches to muscular dystrophy.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

G4 motifs correlate with promoter-proximal transcriptional pausing in human genes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disability

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

DBASS3 and DBASS5: databases of aberrant 3'- and 5'-splice sites

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Allele-specific recognition of the 3' splice site of INS intron 1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

5'-UTR G-quadruplex structures acting as translational repressors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

An antisense microwalk reveals critical role of an intronic position linked to a unique long-distance interaction in pre-mRNA splicing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Functional selection and systematic analysis of intronic splicing elements identify active sequence motifs and associated splicing factors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Repression of translation of human estrogen receptor alpha by G-quadruplex formation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

The spliceosome: design principles of a dynamic RNP machine

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Delivery of bifunctional RNAs that target an intronic repressor and increase SMN levels in an animal model of spinal muscular atrophy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

A G-tract element in apoptotic agents-induced alternative splicing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Functional importance of different patterns of correlation between adjacent cassette exons in human and mouse

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Insulin as an autoantigen in NOD/human diabetes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Antisense-mediated exon skipping: a versatile tool with therapeutic and research applications

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Correction of prototypic ATM splicing mutations and aberrant ATM function with antisense morpholino oligonucleotides

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Multivariate analysis and visualization of splicing correlations in single-gene transcriptomes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Extreme genetic risk for type 1A diabetes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

RNA interference knockdown of hU2AF35 impairs cell cycle progression and modulates alternative splicing of Cdc25 transcripts

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Variants in the human insulin gene that affect pre-mRNA splicing: is -23HphI a functional single nucleotide polymorphism at IDDM2?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Identification of splicing silencers and enhancers in sense Alus: a role for pseudoacceptors in splice site repression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Diversity of vertebrate splicing factor U2AF35: identification of alternatively spliced U2AF1 mRNAS.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

RNA folding affects the recruitment of SR proteins by mouse and human polypurinic enhancer elements in the fibronectin EDA exon

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Global haplotype diversity in the human insulin gene region

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

How introns influence and enhance eukaryotic gene expression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Optimized RNA targets of two closely related triple KH domain proteins, heterogeneous nuclear ribonucleoprotein K and alphaCP-2KL, suggest Distinct modes of RNA recognition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Alternative pre-mRNA splicing: the logic of combinatorial control

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Translational pathophysiology: a novel molecular mechanism of human disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Redefinition of exon 7 in the COL1A1 gene of type I collagen by an intron 8 splice-donor-site mutation in a form of osteogenesis imperfecta: influence of intron splice order on outcome of splice-site mutation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

The splicing factors 9G8 and SRp20 transactivate splicing through different and specific enhancers.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Regulation of insulin preRNA splicing by glucose

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

A genome-wide search for human type 1 diabetes susceptibility genes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

An intronic (A/U)GGG repeat enhances the splicing of an alternative intron of the chicken beta-tropomyosin pre-mRNA

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Conserved quartets near 5' intron junctions in primate nuclear pre-mRNA.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Comparison of intron-dependent and intron-independent gene expression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Introns increase gene expression in cultured maize cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Surveying cis-acting sequences of pre-mRNA by adding antisense 2'-O-methyl oligoribonucleotides to a splicing reaction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Hairpin and parallel quartet structures for telomeric sequences.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081105

Remapping the insulin gene/IDDM2 locus in type 1 diabetes.

28 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU507

Phenotypic consequences of branch point substitutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU507

The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU507

Position-dependent repression and promotion of DQB1 intron 3 splicing by GGGG motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU507

G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU507

Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU507

An RNA hairpin to G-quadruplex conformational transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU507

Essential role for the interaction between hnRNP H/F and a G quadruplex in maintaining p53 pre-mRNA 3'-end processing and function during DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU507

2D meets 4G: G-quadruplexes in RNA secondary structure prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU507

The multiassembly problem: reconstructing multiple transcript isoforms from EST fragment mixtures

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU507

A polar mechanism coordinates different regions of alternative splicing within a single gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU507

21 January 2018

Quadruplex Nucleic Acids

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU507

Occurrence of a Quadruplex Motif in a Unique Insert within Exon C of the Bovine Estrogen Receptor α Gene (ESR1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU507

The kinetics and folding pathways of intramolecular G-quadruplex nucleic acids

21 January 2018

1 reference

12 December 2020

A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly

1 reference

12 December 2020

RNA quadruplex-based modulation of gene expression

1 reference

12 December 2020

An RNA G-quadruplex is essential for cap-independent translation initiation in human VEGF IRES

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKU507

1 reference

29 July 2017

1 reference

29 July 2017

1 reference