Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2 (Q33843105)

29 July 2017

Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2 (English)

1 reference

29 July 2017

1 reference

Deanna N Edwards

1

0 references

author name string

David K Orren

series ordinal

2

1 reference

PubMed ID

24880691

29 July 2017

Amrita Machwe

series ordinal

3

1 reference

PubMed ID

24880691

29 July 2017

language of work or name

English

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publication date

31 May 2014

1 reference

29 July 2017

Nucleic Acids Research

1 reference

29 July 2017

42

1 reference

29 July 2017

12

1 reference

29 July 2017

7748-7761

1 reference

Creative Commons Attribution-NonCommercial 3.0 Unported

29 July 2017

start time

4 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4081078/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Hyper telomere recombination accelerates replicative senescence and may promote premature aging

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

How shelterin protects mammalian telomeres

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Break-induced replication: what is it and what is it for?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Replication fork regression in vitro by the Werner syndrome protein (WRN): holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

The Werner and Bloom syndrome proteins catalyze regression of a model replication fork

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

DNA helicases required for homologous recombination and repair of damaged replication forks

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Homologous recombination generates T-loop-sized deletions at human telomeres

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Role of Saccharomyces single-stranded DNA-binding protein RPA in the strand invasion step of double-strand break repair

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

DNA damage foci at dysfunctional telomeres

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Rad52 protein associates with replication protein A (RPA)-single-stranded DNA to accelerate Rad51-mediated displacement of RPA and presynaptic complex formation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Werner syndrome cells are sensitive to DNA cross-linking drugs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

TRF1 binds a bipartite telomeric site with extreme spatial flexibility

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Mammalian telomeres end in a large duplex loop

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

TRF2 Protects Human Telomeres from End-to-End Fusions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Telomeric localization of TRF2, a novel human telobox protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

The Werner syndrome protein is a DNA helicase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

TRF1 is a dimer and bends telomeric DNA

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Control of telomere length by the human telomeric protein TRF1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Excess of rare cancers in Werner syndrome (adult progeria)

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Positional cloning of the Werner's syndrome gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

The Bloom's syndrome gene product is homologous to RecQ helicases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Mutator phenotype of Werner syndrome is characterized by extensive deletions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

A mammalian factor that binds telomeric TTAGGG repeats in vitro

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081078

Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism

28 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU454

Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU454

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU454

The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU454

Cell cycle-regulated association between the Werner syndrome protein and its molecular partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU454

TRF2 promotes, remodels and protects telomeric Holliday junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU454

Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU454

Telomere dysfunction as a cause of genomic instability in Werner syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU454

Werner syndrome protein contains three structure-specific DNA binding domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU454

Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU454

Werner syndrome helicase activity is essential in maintaining fragile site stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU454

Break-induced replication and recombinational telomere elongation in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU454

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU454

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

21 January 2018

1 reference

12 December 2020

Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing

1 reference

12 December 2020

The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeats

1 reference

12 December 2020

DNase I footprinting and enhanced exonuclease function of the bipartite Werner syndrome protein (WRN) bound to partially melted duplex DNA

1 reference

12 December 2020

Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase

1 reference

12 December 2020

Impaired nuclear localization of defective DNA helicases in Werner's syndrome

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKU454

1 reference

29 July 2017

1 reference

29 July 2017

1 reference

PubMed ID

24880691