Werner syndrome protein contains three structure-specific DNA binding domains (Q44611028)

4 December 2017

title

Werner syndrome protein contains three structure-specific DNA binding domains (English)

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4 December 2017

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5

Vilhelm A Bohr

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4 December 2017

1

Cayetano von Kobbe

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4 December 2017

Nicolas H Thomä

2

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4 December 2017

Bryan K Czyzewski

series ordinal

3

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4 December 2017

Nikola P Pavletich

series ordinal

4

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4 December 2017

publication date

8 October 2003

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Journal of Biological Chemistry

4 December 2017

language of work or name

English

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number of pages

10

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based on heuristic

inferred from page(s)

published in

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4 December 2017

volume

278

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4 December 2017

issue

52

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4 December 2017

page(s)

52997-53006

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Positional cloning of the Werner's syndrome gene

4 December 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M308338200

RecQ family helicases: roles in cancer and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

The Werner syndrome protein is a DNA helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Functional and physical interaction between WRN helicase and human replication protein A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

p53-mediated apoptosis is attenuated in Werner syndrome cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308338200

Werner protein recruits DNA polymerase delta to the nucleolus

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308338200

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308338200

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308338200

Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Selective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Characterization and mutational analysis of the RecQ core of the bloom syndrome protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Domain mapping of Escherichia coli RecQ defines the roles of conserved N- and C-terminal regions in the RecQ family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

High-resolution structure of the E.coli RecQ helicase catalytic core

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

WRN mutations in Werner syndrome

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308338200

DNA damage-induced translocation of the Werner helicase is regulated by acetylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308338200

Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Inhibition of the Bloom's and Werner's Syndrome Helicases by G-Quadruplex Interacting Ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

The processing of Holliday junctions by BLM and WRN helicases is regulated by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Werner and Bloom helicases are involved in DNA repair in a complementary fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Functions of RecQ family helicases: possible involvement of Bloom's and Werner's syndrome gene products in guarding genome integrity during DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Bloom’s and Werner’s syndrome genes suppress hyperrecombination in yeast sgs1 mutant: Implication for genomic instability in human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Homologous recombination is elevated in some Werner-like syndromes but not during normal in vitro or in vivo senescence of mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Asymmetry of DNA replication fork progression in Werner's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Impaired nuclear localization of defective DNA helicases in Werner's syndrome

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308338200

A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308338200

Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308338200

21 January 2018

Identifiers

DOI

10.1074/JBC.M308338200

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4 December 2017

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