Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases (Q24304488)

Telomeric repeat binding factor 2

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BLM RecQ like helicase

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protein C-terminus binding

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6

Vilhelm A Bohr

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author name string

Patricia L Opresko

1

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Cayetano von Kobbe

2

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Jean-Philippe Laine

3

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Jeanine Harrigan

4

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Ian D Hickson

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

25 October 2002

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published in

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volume

277

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issue

43

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page(s)

41110-9

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cites work

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Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes

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DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders

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Mutator phenotype of Werner syndrome is characterized by extensive deletions

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Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines

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Positional cloning of the Werner's syndrome gene

21 January 2018

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The Werner syndrome protein is a DNA helicase

21 January 2018

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The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

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Cellular senescence, cancer and aging: the telomere connection

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Telomere states and cell fates

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Control of human telomere length by TRF1 and TRF2

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TRF2 Protects Human Telomeres from End-to-End Fusions

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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

21 January 2018

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Mammalian telomeres end in a large duplex loop

21 January 2018

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DNA damage and repair in telomeres: relation to aging

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Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein-Barr virus

21 January 2018

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The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

21 January 2018

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Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase

21 January 2018

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Nuclear structure in normal and Bloom syndrome cells

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Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

21 January 2018

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Oligomeric ring structure of the Bloom's syndrome helicase

21 January 2018

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A mammalian factor that binds telomeric TTAGGG repeats in vitro

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Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

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Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

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Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

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Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein

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p53 Modulates the exonuclease activity of Werner syndrome protein

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Werner syndrome protein: biochemical properties and functional interactions

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Nucleolar localization of the Werner syndrome protein in human cells

21 January 2018

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Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.

21 January 2018

1 reference

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Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

21 January 2018

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The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

21 January 2018

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TRF1 binds a bipartite telomeric site with extreme spatial flexibility

21 January 2018

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Functional and physical interaction between WRN helicase and human replication protein A

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Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells

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Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

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DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

21 January 2018

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Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit

21 January 2018

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Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase

21 January 2018

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Interaction of human Ku70 with TRF2

21 January 2018

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Defending genome integrity during DNA replication: a proposed role for RecQ family helicases

21 January 2018

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7 January 2021

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

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7 January 2021

Chromosome instability in lymphocytes from a patient with Werner's syndrome is not associated with DNA repair defects

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https://api.crossref.org/works/10.1074%2FJBC.M205396200

7 January 2021

SGS1 is required for telomere elongation in the absence of telomerase

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https://api.crossref.org/works/10.1074%2FJBC.M205396200

7 January 2021

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

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7 January 2021

Impaired nuclear localization of defective DNA helicases in Werner's syndrome

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7 January 2021

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

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7 January 2021

Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease

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7 January 2021