Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. (Q36146840)

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15 January 2020

title

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations (English)

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15 January 2020

1

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15 January 2020

Ross A. Dickins

9

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15 January 2020

author name string

Mila Jankovic

2

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15 January 2020

Elsa Callen

3

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15 January 2020

Simone Difilippantonio

4

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15 January 2020

Hua-Tang Chen

5

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15 January 2020

Kevin M McBride

6

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15 January 2020

Thomas R Eisenreich

7

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15 January 2020

Junjie Chen

8

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15 January 2020

Scott W Lowe

10

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15 January 2020

Andre Nussenzweig

11

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15 January 2020

Michel C Nussenzweig

12

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15 January 2020

publication date

8 January 2006

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15 January 2020

language of work or name

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15 January 2020

volume

440

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15 January 2020

issue

7080

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15 January 2020

page(s)

105-109

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53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice

15 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Inducible DNA breaks in Ig S regions are dependent on AID and UNG

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Nibrin functions in Ig class-switch recombination

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

ATM is required for efficient recombination between immunoglobulin switch regions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Immunoglobulin class switch recombination is impaired in Atm-deficient mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

53BP1 is required for class switch recombination

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Tumor suppression by Ink4a-Arf: progress and puzzles

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

DNA-dependent protein kinase activity is not required for immunoglobulin class switching

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

IL-6 transgenic mouse model for extraosseous plasmacytoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Mechanisms of chromosomal translocations in B cell lymphomas

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Plasmacytomagenesis in mice: model of neoplastic development dependent upon chromosomal translocations

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Ku80 is required for immunoglobulin isotype switching

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Chromosomal translocations deregulating c-myc are associated with normal immune responses

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

AID is required for c-myc/IgH chromosome translocations in vivo

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601098

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16400328

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16400328

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE04495

1 reference

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Dimensions Publication ID

15 January 2020

0 references

1 reference

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15 January 2020

PubMed publication ID

16400328

1 reference