Modes of regulation of ubiquitin-mediated protein degradation (Q33776751)

29 July 2017

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title

Modes of regulation of ubiquitin-mediated protein degradation (English)

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29 July 2017

2

A Ciechanover

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29 July 2017

D Kornitzer

1

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29 July 2017

1 January 2000

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Journal of Cellular Physiology

29 July 2017

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29 July 2017

182

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29 July 2017

1-11

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29 July 2017

1

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beta-catenin is a target for the ubiquitin-proteasome pathway

29 July 2017

1 reference

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Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.

21 January 2018

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

21 January 2018

1 reference

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The proteasome: paradigm of a self-compartmentalizing protease

21 January 2018

1 reference

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The base of the proteasome regulatory particle exhibits chaperone-like activity

21 January 2018

1 reference

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A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein.

21 January 2018

1 reference

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Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

21 January 2018

1 reference

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

21 January 2018

1 reference

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Degradation of nuclear oncoproteins by the ubiquitin system in vitro

21 January 2018

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Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation

21 January 2018

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Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p

21 January 2018

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Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

21 January 2018

1 reference

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Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway.

21 January 2018

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The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

21 January 2018

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A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

21 January 2018

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The murine gene p27Kip1 is haplo-insufficient for tumour suppression

21 January 2018

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A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae

21 January 2018

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HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin.

21 January 2018

1 reference

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Ubiquitination mediated by the Npi1p/Rsp5p ubiquitin-protein ligase is required for endocytosis of the yeast uracil permease

21 January 2018

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Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein

21 January 2018

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

21 January 2018

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A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.

21 January 2018

1 reference

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Structure of 20S proteasome from yeast at 2.4 A resolution

21 January 2018

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Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway

21 January 2018

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Coordinated induction of the ubiquitin conjugation pathway accompanies the developmentally programmed death of insect skeletal muscle

21 January 2018

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The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

21 January 2018

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Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast

21 January 2018

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The dose of a putative ubiquitin-specific protease affects position-effect variegation in Drosophila melanogaster

21 January 2018

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Mechanisms of Intracellular Protein Breakdown

21 January 2018

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Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels

21 January 2018

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Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

21 January 2018

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Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

21 January 2018

1 reference

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A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

21 January 2018

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Control of cell fate by a deubiquitinating enzyme encoded by the fat facets gene.

21 January 2018

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Budding yeast Cdc20: a target of the spindle checkpoint.

21 January 2018

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Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast

21 January 2018

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Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

21 January 2018

1 reference

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Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.

21 January 2018

1 reference

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Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway.

21 January 2018

1 reference

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

21 January 2018

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Homology in structural organization between E. coli ClpAP protease and the eukaryotic 26 S proteasome

21 January 2018

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A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

21 January 2018

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UBE3A/E6-AP mutations cause Angelman syndrome

21 January 2018

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An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

21 January 2018

1 reference

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A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

21 January 2018

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Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP.

21 January 2018

1 reference

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Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity

21 January 2018

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The mouse and human genes encoding the recognition component of the N-end rule pathway

21 January 2018

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Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase

21 January 2018

1 reference

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The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

21 January 2018

1 reference

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A glycine-rich region in NF-kappaB p105 functions as a processing signal for the generation of the p50 subunit

21 January 2018

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Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

21 January 2018

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A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

21 January 2018

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Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

21 January 2018

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De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome.

21 January 2018

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Multiple signals converging on NF-kappaB.

21 January 2018

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IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

21 January 2018

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Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway

21 January 2018

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A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae

21 January 2018

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Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

21 January 2018

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ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

21 January 2018

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Structural motifs involved in ubiquitin-mediated processing of the NF-kappaB precursor p105: roles of the glycine-rich region and a downstream ubiquitination domain

21 January 2018

1 reference

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Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation

21 January 2018

1 reference

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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

21 January 2018

1 reference

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

21 January 2018

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Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

21 January 2018

1 reference

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Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast

21 January 2018

1 reference

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Retrograde protein translocation: ERADication of secretory proteins in health and disease

21 January 2018

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Regulation of enzyme levels by proteolysis: the role of pest regions

21 January 2018

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Degradation of cell proteins and the generation of MHC class I-presented peptides

21 January 2018

1 reference

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Stabilization of beta-catenin by genetic defects in melanoma cell lines

21 January 2018

1 reference

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Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.

21 January 2018

1 reference

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Does this have a familiar RING?

21 January 2018

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

21 January 2018

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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

21 January 2018

1 reference

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Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

21 January 2018

1 reference

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Yeast Hct1 is a regulator of Clb2 cyclin proteolysis

21 January 2018

1 reference

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The ubiquitin-proteasome pathway and pathogenesis of human diseases

21 January 2018

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The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Cyclin E-CDK2 is a regulator of p27Kip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

A ubiquitin mutant with specific defects in DNA repair and multiubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Nitrogen-regulated ubiquitination of the Gap1 permease of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Degradation of the proto-oncogene product c-Fos by the ubiquitin proteolytic system in vivo and in vitro: identification and characterization of the conjugating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Degradation of c-Fos by the 26S proteasome is accelerated by c-Jun and multiple protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

The multiubiquitin-chain-binding protein Mcb1 is a component of the 26S proteasome in Saccharomyces cerevisiae and plays a nonessential, substrate-specific role in protein turnover.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

The N-end rule: functions, mysteries, uses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

A molecular chaperone, ClpA, functions like DnaK and DnaJ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

p34Cdc28-mediated control of Cln3 cyclin degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Identification of a cullin homology region in a subunit of the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

DUB-1, a deubiquitinating enzyme with growth-suppressing activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

Characterization of Human hect Domain Family Members and Their Interaction with UbcH5 and UbcH7

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291097-4652%28200001%29182%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-V

10.1002/(SICI)1097-4652(200001)182:1<1::AID-JCP1>3.0.CO;2-V

21 January 2018

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10567911