MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. (Q33694927)

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18 January 2020

title

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele (English)

1 reference

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18 January 2020

6

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18 January 2020

Patricia Ernst

9

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18 January 2020

author name string

Austin T Thiel

1

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18 January 2020

Peter Blessington

2

1 reference

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18 January 2020

Tao Zou

3

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18 January 2020

Danielle Feather

4

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18 January 2020

Xinjiang Wu

5

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18 January 2020

Hui Zhang

7

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18 January 2020

Zuguo Liu

8

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18 January 2020

Gary A Koretzky

10

1 reference

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18 January 2020

Xianxin Hua

11

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18 January 2020

publication date

1 February 2010

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18 January 2020

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18 January 2020

volume

17

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18 January 2020

issue

2

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18 January 2020

page(s)

148-159

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Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

18 January 2020

cites work

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H3K79 methylation profiles define murine and human MLL-AF4 leukemias

21 June 2018

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21 June 2018

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The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele

21 June 2018

1 reference

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Menin critically links MLL proteins with LEDGF on cancer-associated target genes

21 June 2018

1 reference

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Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia

21 June 2018

1 reference

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Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells

21 June 2018

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Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors

21 June 2018

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Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

21 June 2018

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DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

21 June 2018

1 reference

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MLL translocations, histone modifications and leukaemia stem-cell development

21 June 2018

1 reference

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Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions

21 June 2018

1 reference

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Non-oncogene addiction and the stress phenotype of cancer cells

21 June 2018

1 reference

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A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

21 June 2018

1 reference

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The complex language of chromatin regulation during transcription

21 June 2018

1 reference

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Modeling the initiation and progression of human acute leukemia in mice

21 June 2018

1 reference

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Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Myc-binding-site recognition in the human genome is determined by chromatin context

21 June 2018

1 reference

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Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Double chromodomains cooperate to recognize the methylated histone H3 tail

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development

21 June 2018

1 reference

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Global and Hox-specific roles for the MLL1 methyltransferase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

hDOT1L links histone methylation to leukemogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

MLL: how complex does it get?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

MLL: a histone methyltransferase disrupted in leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Direct binding of DNA by tumor suppressor menin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Menin associates with FANCD2, a protein involved in repair of DNA damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

MLL targets SET domain methyltransferase activity to Hox gene promoters

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830208

The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20159607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Interaction of MLL amino terminal sequences with menin is required for transformation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20159607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2009.12.034

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20159607%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20159607%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

20159607

1 reference