Effect of metals on kinetic pathways of amyloid-β aggregation (Q33649803)

28 July 2017

5 references

25 April 2019

4 November 2019

20 November 2019

15 December 2019

1 May 2021

Effect of metals on kinetic pathways of amyloid-β aggregation (English)

1 reference

28 July 2017

4 references

25 April 2019

4 November 2019

20 November 2019

15 December 2019

1 reference

4 November 2019

1 reference

20 November 2019

1 reference

15 December 2019

1 reference

1 May 2021

Francis Hane

1

1 reference

PubMed ID

24970207

28 July 2017

Zoya Leonenko

series ordinal

2

1 reference

28 July 2017

10 January 2014

6 references

28 July 2017

25 April 2019

4 November 2019

20 November 2019

15 December 2019

1 May 2021

6 references

28 July 2017

25 April 2019

4 November 2019

20 November 2019

15 December 2019

1 May 2021

4

1 reference

28 July 2017

1

1 reference

28 July 2017

101-116

1 reference

Creative Commons Attribution 3.0 Unported

28 July 2017

5 references

25 April 2019

4 November 2019

20 November 2019

15 December 2019

on focus list of Wikimedia project

1 May 2021

copyright status

copyrighted

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ScienceSource

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cites work

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance

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Structural insights into Aβ42 oligomers using site-directed spin labeling

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Role of metal ions in the self-assembly of the Alzheimer's amyloid-β peptide.

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Cu(2+) affects amyloid-β (1-42) aggregation by increasing peptide-peptide binding forces

21 June 2018

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Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.

21 June 2018

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Local structure and global patterning of Cu2+ binding in fibrillar amyloid-β [Aβ(1-40)] protein

21 June 2018

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Copper and oxidative stress in the pathogenesis of Alzheimer's disease

21 June 2018

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Toxic fibrillar oligomers of amyloid-β have cross-β structure

21 June 2018

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Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity

21 June 2018

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Dimer formation enhances structural differences between amyloid β-protein (1-40) and (1-42): an explicit-solvent molecular dynamics study

21 June 2018

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Structural features and cytotoxicity of amyloid oligomers: implications in Alzheimer's disease and other diseases with amyloid deposits

21 June 2018

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Atomic View of a Toxic Amyloid Small Oligomer

21 June 2018

1 reference

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Antiparallel -sheet architecture in Iowa-mutant -amyloid fibrils

21 June 2018

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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

21 June 2018

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Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology

21 June 2018

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On the involvement of copper binding to the N-terminus of the amyloid Beta Peptide of Alzheimer's disease: a computational study on model systems

21 June 2018

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Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils

21 June 2018

1 reference

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Effect of surfaces on amyloid fibril formation

21 June 2018

1 reference

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Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

21 June 2018

1 reference

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Polymorphic structures of Alzheimer's β-amyloid globulomers.

21 June 2018

1 reference

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Aluminum, copper, iron and zinc differentially alter amyloid-Aβ(1-42) aggregation and toxicity

21 June 2018

1 reference

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Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity

21 June 2018

1 reference

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Role of metal dyshomeostasis in Alzheimer's disease

21 June 2018

1 reference

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Two distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analyses

21 June 2018

1 reference

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β-Barrel topology of Alzheimer's β-amyloid ion channels

21 June 2018

1 reference

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Multidimensional atomic force microscopy: a versatile novel technology for nanopharmacology research

21 June 2018

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Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

21 June 2018

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Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

21 June 2018

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Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation

21 June 2018

1 reference

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Copper and zinc binding to amyloid-beta: coordination, dynamics, aggregation, reactivity and metal-ion transfer

21 June 2018

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Role of small oligomers on the amyloidogenic aggregation free-energy landscape

21 June 2018

1 reference

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The chemistry of Alzheimer's disease

21 June 2018

1 reference

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Effect of beta-sheet propensity on peptide aggregation

21 June 2018

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Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide

21 June 2018

1 reference

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Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer

21 June 2018

1 reference

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Molecular structural basis for polymorphism in Alzheimer's -amyloid fibrils

21 June 2018

1 reference

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Structural classification of toxic amyloid oligomers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030978

Therapeutics for Alzheimer's disease based on the metal hypothesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030978

Zinc at glutamatergic synapses.

21 June 2018

1 reference

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Binding of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-beta peptide

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030978

Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030978

Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm

21 June 2018

1 reference

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The redox chemistry of the Alzheimer's disease amyloid beta peptide.

21 June 2018

1 reference

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Protein misfolding, functional amyloid, and human disease

21 June 2018

1 reference

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Recent atomic models of amyloid fibril structure

21 June 2018

1 reference

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3D structure of Alzheimer's amyloid-beta(1-42) fibrils

21 June 2018

1 reference

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Molecular dynamics simulations of Alzheimer's beta-amyloid protofilaments

21 June 2018

1 reference

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Amyloid ion channels: a common structural link for protein-misfolding disease

21 June 2018

1 reference

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Structure of the cross-beta spine of amyloid-like fibrils

21 June 2018

1 reference

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The neurobiology of zinc in health and disease

21 June 2018

1 reference

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Molecular basis for amyloid fibril formation and stability

21 June 2018

1 reference

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Metals in our minds: therapeutic implications for neurodegenerative disorders

21 June 2018

1 reference

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Modeling amyloid beta-peptide insertion into lipid bilayers

21 June 2018

1 reference

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Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

21 June 2018

1 reference

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 June 2018

1 reference

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Stabilities and conformations of Alzheimer's beta -amyloid peptide oligomers (Abeta 16-22, Abeta 16-35, and Abeta 10-35): Sequence effects

21 June 2018

1 reference

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Supramolecular structure in full-length Alzheimer's beta-amyloid fibrils: evidence for a parallel beta-sheet organization from solid-state nuclear magnetic resonance

21 June 2018

1 reference

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030978

Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030978

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030978

Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030978

Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of beta-sheets in Alzheimer's beta-amyloid fibrils

21 June 2018

1 reference

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Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

21 June 2018

1 reference

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The mechanism of "Fenton-like" reactions and their importance for biological systems. A biologist's view

21 June 2018

1 reference

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 June 2018

1 reference

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Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

21 June 2018

1 reference

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Oxidative stress hypothesis in Alzheimer's disease

21 June 2018

1 reference

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Rapid induction of Alzheimer A beta amyloid formation by zinc.

21 June 2018

1 reference

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X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation

21 June 2018

1 reference

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Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability

21 June 2018

1 reference

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Copper, zinc, magnesium, and calcium in plasma and cerebrospinal fluid of patients with neurological diseases

21 June 2018

1 reference

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Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct

21 June 2018

1 reference

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A disulfide-linked amyloid-beta peptide dimer forms a protofibril-like oligomer through a distinct pathway from amyloid fibril formation

21 January 2018

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Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid

21 January 2018

1 reference

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Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.

21 January 2018

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Why is the amyloid beta peptide of Alzheimer's disease neurotoxic?

21 January 2018

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Structure of the 21-30 fragment of amyloid beta-protein.

21 January 2018

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Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-beta protein.

21 January 2018

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Nanoscale electrostatic domains in cholesterol-laden lipid membranes create a target for amyloid binding

21 January 2018

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Two types of Alzheimer's beta-amyloid (1-40) peptide membrane interactions: aggregation preventing transmembrane anchoring versus accelerated surface fibril formation.

21 January 2018

1 reference

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Amyloid-forming proteins alter the local mechanical properties of lipid membranes.

21 January 2018

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Abeta42-peptide assembly on lipid bilayers

21 January 2018

1 reference

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Cu(II) mediates kinetically distinct, non-amyloidogenic aggregation of amyloid-beta peptides

21 January 2018

1 reference

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Identifying the minimal copper- and zinc-binding site sequence in amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM4010101

Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM4010101

Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization.

21 January 2018

1 reference

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Diversity of kinetic pathways in amyloid fibril formation

21 January 2018

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In vitro growth of Alzheimer's disease beta-amyloid plaques displays first-order kinetics.

21 January 2018

1 reference

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Metal ions differentially influence the aggregation and deposition of Alzheimer's beta-amyloid on a solid template.

21 January 2018

1 reference

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Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM4010101

Molecular modeling of zinc and copper binding with Alzheimer's amyloid beta-peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM4010101

The amyloid beta peptide (Abeta(1-40)) is thermodynamically soluble at physiological concentrations

21 January 2018

1 reference

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Coordination abilities of the 1-16 and 1-28 fragments of beta-amyloid peptide towards copper(II) ions: a combined potentiometric and spectroscopic study

21 January 2018

1 reference

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Quantification of the binding constant of copper(II) to the amyloid-beta peptide

21 January 2018

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Copper(II) binding to amyloid-beta fibrils of Alzheimer's disease reveals a picomolar affinity: stoichiometry and coordination geometry are independent of Abeta oligomeric form

21 January 2018

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Protection against amyloid beta peptide toxicity by zinc.

21 January 2018

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Effect of zinc ions on the cytotoxicity induced by the amyloid beta-peptide.

21 January 2018

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Trace copper(II) or zinc(II) ions drastically modify the aggregation behavior of amyloid-beta1-42: an AFM study.

21 January 2018

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In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

30 October 2018

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Surfactant properties of Alzheimer's A beta peptides and the mechanism of amyloid aggregation.

30 October 2018

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Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

30 October 2018

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12 December 2020

Watching amyloid fibrils grow by time-lapse atomic force microscopy

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12 December 2020

Amyloid-β aggregation on model lipid membranes: an atomic force microscopy study

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12 December 2020

Dead-end street of protein folding: thermodynamic rationale of amyloid fibril formation

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12 December 2020

Zinc Lowers Amyloid-β Toxicity by Selectively Precipitating Aggregation Intermediates†

1 reference

12 December 2020

Quantitative analysis of amyloid beta peptides in cerebrospinal fluid of Alzheimer's disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negative electrospray ionization tandem mass spectrometry

1 reference

12 December 2020

Identifiers

DOI

10.3390/BIOM4010101

1 reference

28 July 2017

1 reference

28 July 2017

1 reference

PubMed ID

24970207