Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates (Q33612459)

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English	Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates	scientific article

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28 July 2017

Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates (English)

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28 July 2017

Baptiste Aussedat

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Baptiste Aussedat

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Bette Korber

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William E Walkowicz

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William E Walkowicz

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Yusuf Vohra

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Dan H Barouch

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David C. Montefiori

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David C Montefiori

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Barton F Haynes

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Gary J Nabel

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Rogier W Sanders

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Rogier W Sanders

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Georgia D. Tomaras

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Georgia D Tomaras

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Norman L. Letvin

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Norman L Letvin

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Kevin O Saunders

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Kevin O Saunders

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Richard M Scearce

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Richard M Scearce

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Sampa Santra

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Nathan I Nicely

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Nathan I Nicely

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S Munir Alam

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Ruijun Zhang

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Hua-Xin Liao

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Laura L Sutherland

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Laura L Sutherland

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Thomas B. Kepler

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Thomas B Kepler

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Samuel J. Danishefsky

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Samuel J Danishefsky

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Kevin Wiehe

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Mattia Bonsignori

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Mattia Bonsignori

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R Ryan Meyerhoff

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R Ryan Meyerhoff

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Fangping Cai

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Amanda Eaton

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Kara Anasti

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M Anthony Moody

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M Anthony Moody

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Robert Parks

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Tarra Von Holle

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Tarra Von Holle

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author name string

Nelson R Wu

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Peter K Park

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Eden P Go

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R Glenn Overman

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Heather Desaire

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publication date

1 February 2017

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2175-2188

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28 July 2017

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.

1 reference

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21 June 2018

Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

1 reference

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21 June 2018

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

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21 June 2018

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires

1 reference

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21 June 2018

Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice

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21 June 2018

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

1 reference

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21 June 2018

A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans.

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21 June 2018

HIV-1 Neutralizing Antibodies with Limited Hypermutation from an Infant

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21 June 2018

Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch

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21 June 2018

Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages

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21 June 2018

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

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21 June 2018

Complex Antigens Drive Permissive Clonal Selection in Germinal Centers

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21 June 2018

Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site

1 reference

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21 June 2018

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

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21 June 2018

Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.

1 reference

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21 June 2018

The HIV glycan shield as a target for broadly neutralizing antibodies

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21 June 2018

Antibodies elicited by yeast glycoproteins recognize HIV-1 virions and potently neutralize virions with high mannose N-glycans

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21 June 2018

HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

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21 June 2018

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

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21 June 2018

Comparative Analysis of the Glycosylation Profiles of Membrane-Anchored HIV-1 Envelope Glycoprotein Trimers and Soluble gp140

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21 June 2018

Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved

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21 June 2018

Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope

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21 June 2018

Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies

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21 June 2018

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

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21 June 2018

Structural evolution of glycan recognition by a family of potent HIV antibodies

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21 June 2018

Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies

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21 June 2018

Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy

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21 June 2018

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21 June 2018

Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers

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21 June 2018

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

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21 June 2018

Reconstructing a B-cell clonal lineage. I. Statistical inference of unobserved ancestors

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21 June 2018

Ending AIDS--is an HIV vaccine necessary?

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21 June 2018

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

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21 June 2018

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

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21 June 2018

HIV-1 neutralizing antibodies: understanding nature's pathways

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21 June 2018

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

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21 June 2018

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

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21 June 2018

Antigenicity and immunogenicity of transmitted/founder, consensus, and chronic envelope glycoproteins of human immunodeficiency virus type 1

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21 June 2018

Characterization of host-cell line specific glycosylation profiles of early transmitted/founder HIV-1 gp120 envelope proteins

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21 June 2018

Broadly neutralizing antiviral antibodies

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21 June 2018

Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo

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21 June 2018

A Blueprint for HIV Vaccine Discovery

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21 June 2018

B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study

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21 June 2018

HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages

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21 June 2018

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

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21 June 2018

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

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21 June 2018

The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade.

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21 June 2018

Broad neutralization coverage of HIV by multiple highly potent antibodies

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21 June 2018

The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection

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21 June 2018

Yeast-elicited cross-reactive antibodies to HIV Env glycans efficiently neutralize virions expressing exclusively high-mannose N-linked glycans

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21 June 2018

A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity

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21 June 2018

A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals

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21 June 2018

Variable loop glycan dependency of the broad and potent HIV-1-neutralizing antibodies PG9 and PG16.

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21 June 2018

Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens.

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21 June 2018

Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds

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21 June 2018

Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function

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21 June 2018

The role of antibodies in HIV vaccines

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21 June 2018

Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans

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21 June 2018

Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target

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21 June 2018

Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm

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21 June 2018

Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection

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21 June 2018

Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies

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21 June 2018

An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions

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21 June 2018

PBEQ-Solver for online visualization of electrostatic potential of biomolecules

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21 June 2018

A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120

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21 June 2018

Glycosylation site-specific analysis of HIV envelope proteins (JR-FL and CON-S) reveals major differences in glycosylation site occupancy, glycoform profiles, and antigenic epitopes' accessibility

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21 June 2018

Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN

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21 June 2018

Exploiting the defensive sugars of HIV-1 for drug and vaccine design

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21 June 2018

Inhibition of hybrid- and complex-type glycosylation reveals the presence of the GlcNAc transferase I-independent fucosylation pathway

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21 June 2018

Antiviral antibody responses: the two extremes of a wide spectrum

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21 June 2018

SoDA: implementation of a 3D alignment algorithm for inference of antigen receptor recombinations

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21 June 2018

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition

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21 June 2018

Antibody neutralization and escape by HIV-1

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21 June 2018

Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line

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21 June 2018

The antiviral activity of antibodies in vitro and in vivo.

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21 June 2018

Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells

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21 June 2018

High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies

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30 October 2018

Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5408352

30 October 2018

CHARMM-GUI: a web-based graphical user interface for CHARMM

1 reference

https://pubmed.ncbi.nlm.nih.gov/28249163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibodies to the Cryptococcus neoformans capsular glucuronoxylomannan are ubiquitous in serum from HIV+ and HIV- individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/28249163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CELREP.2017.02.003

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

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