A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity (Q27664589)

(6S)-6-C-methyl-D-mannopyranose

ChEBI release 2020-05-28

ChEBI ID

41005

1 reference

6-C-Me-alpha-D-Manp-(1->2)-alpha-D-Manp-(1->2)-alpha-D-Manp-(1->3)-alpha-D-Manp

ChEBI release 2020-05-28

ChEBI ID

64171

1 reference

ChEBI release 2020-05-28

Katie J Doores

1

0 references

Mark R Wormald

Mark R Wormald

6

0 references

Ian Andrew Wilson

9

Ian A Wilson

0 references

M. G. Finn

7

M G Finn

0 references

Dennis R. Burton

8

Dennis R Burton

0 references

author name string

Zara Fulton

2

0 references

Vu Hong

3

0 references

Mitul K Patel

4

0 references

Christopher N Scanlan

5

0 references

Benjamin G Davis

Proceedings of the National Academy of Sciences of the United States of America

10

0 references

language of work or name

English

0 references

publication date

5 October 2010

0 references

published in

0 references

volume

107

0 references

page(s)

17107-12

0 references

issue

40

0 references

cites work

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Structural definition of a conserved neutralization epitope on HIV-1 gp120

20 March 2017

1 reference

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Antibody domain exchange is an immunological solution to carbohydrate cluster recognition

20 March 2017

1 reference

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Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

20 March 2017

1 reference

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20 March 2017

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Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41

20 March 2017

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The antigenic structure of the HIV gp120 envelope glycoprotein

20 March 2017

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Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target

20 March 2017

1 reference

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Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

7 April 2017

1 reference

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Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds

7 April 2017

1 reference

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Analysis and optimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation

29 September 2017

1 reference

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HIV-1 and influenza antibodies: seeing antigens in new ways

29 September 2017

1 reference

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Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers

29 September 2017

1 reference

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A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120

29 September 2017

1 reference

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Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN

29 September 2017

1 reference

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Robust immune responses elicited by a fully synthetic three-component vaccine

29 September 2017

1 reference

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Novel template-assembled oligosaccharide clusters as epitope mimics for HIV-neutralizing antibody 2G12. Design, synthesis, and antibody binding study

29 September 2017

1 reference

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Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12.

29 September 2017

1 reference

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Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

29 September 2017

1 reference

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Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope

29 September 2017

1 reference

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Binding of high-mannose-type oligosaccharides and synthetic oligomannose clusters to human antibody 2G12: implications for HIV-1 vaccine design

29 September 2017

1 reference

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The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5.

29 September 2017

1 reference

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Reactivity-based one-pot synthesis of oligomannoses: defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody

29 September 2017

1 reference

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Design and synthesis of a template-assembled oligomannose cluster as an epitope mimic for human HIV-neutralizing antibody 2G12.

29 September 2017

1 reference

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Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951454

The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951454

The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.

29 September 2017

1 reference

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29 September 2017

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29 September 2017

1 reference

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Glycosylation: heterogeneity and the 3D structure of proteins

29 September 2017

1 reference

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Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III.

29 September 2017

1 reference

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Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency

21 January 2018

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Toward a carbohydrate-based HIV-1 vaccine: synthesis and immunological studies of oligomannose-containing glycoconjugates

21 January 2018

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Chemical and chemoenzymatic synthesis of S-linked ganglioside analogues and their protein conjugates for use as immunogens

21 January 2018

1 reference

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Vaccination of small cell lung cancer patients with polysialic acid or N-propionylated polysialic acid conjugated to keyhole limpet hemocyanin.

21 January 2018

1 reference

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A Trojan horse with a sweet tooth

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20852065

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Fully Synthetic Carbohydrate HIV Antigens Designed on the Logic of the 2G12 Antibody

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20852065