Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region (Q33591104)

28 July 2017

title

Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region (English)

1 reference

28 July 2017

7

F Nina Papavasiliou

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author name string

Wesley A Dunnick

1

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28 July 2017

John T Collins

2

1 reference

28 July 2017

Jian Shi

3

1 reference

28 July 2017

Gerwin Westfield

4

1 reference

28 July 2017

Clinton Fontaine

5

1 reference

28 July 2017

Paul Hakimpour

6

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28 July 2017

F Nina Papavasiliou

7

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28 July 2017

language of work or name

English

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publication date

2 November 2009

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28 July 2017

number of pages

11

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Journal of Experimental Medicine

inferred from page(s)

published in

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28 July 2017

volume

206

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28 July 2017

issue

12

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28 July 2017

page(s)

2613-2623

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A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation

28 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

The 3' end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four gamma genes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Immunoglobulin genes: generating diversity with AID and UNG.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Mechanism and control of class-switch recombination

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Deletional analyses reveal an essential role for the hs3b/hs4 IgH 3' enhancer pair in an Ig-secreting but not an earlier-stage B cell line

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Structural and functional conservation at the boundaries of the chicken beta-globin domain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Molecular processes that regulate class switching

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Idiotype connectance in the immune system. I. Expression of a cross-reactive idiotype on induced anti-p-azophenylarsonate antibodies and on endogenous antibodies not specific for arsonate.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Isotype switching by a microinjected mu immunoglobulin heavy chain gene in transgenic mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Quantitation of immunoglobulin mu-gamma 1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

A plaque assay for all cells secreting Ig of a given type or class

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus

21 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091280

Ig synthesis and class switching do not require the presence of the hs4 enhancer in the 3' IgH regulatory region.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091280

Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091280

Interallelic Class Switch Recombination Contributes Significantly to Class Switching in Mouse B Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091280

Cutting edge: critical role of inducible costimulator in germinal center reactions

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

The gamma 1 heavy chain gene includes all of the cis-acting elements necessary for expression of properly regulated germ-line transcripts

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

Transchromosomally derived Ig heavy chains

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806627

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

31 October 2018

1 reference

12 December 2020

The Ig heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination

1 reference

12 December 2020

Receptors and counterreceptors involved in NK-B cell interactions

1 reference

12 December 2020

Regulation of epsilon germline transcription and switch region mutations by IgH locus 3' enhancers in transgenic mice

1 reference

12 December 2020

Strand-biased spreading of mutations during somatic hypermutation

1 reference

12 December 2020

Cutting edge: IFN-gamma regulated germline transcripts are expressed from gamma2a transgenes independently of the heavy chain 3' enhancers

1 reference

12 December 2020

A pivotal role for DNase I-sensitive regions 3b and/or 4 in the induction of somatic hypermutation of IgH genes

1 reference

12 December 2020

Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination

1 reference

12 December 2020

Switch region content of hybridomas: the two spleen cell Igh loci tend to rearrange to the same isotype

1 reference

12 December 2020

Germ-line transcription occurs on both the functional and the non-functional alleles of immunoglobulin constant heavy chain genes

1 reference

12 December 2020

The immunoglobulin heavy-chain locus hs3b and hs4 3' enhancers are dispensable for VDJ assembly and somatic hypermutation

1 reference

12 December 2020

Germline transcription and switch recombination of a transgene containing the entire H chain constant region locus: effect of a mutation in a STAT6 binding site in the gamma 1 promoter

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20091280

1 reference

28 July 2017

1 reference

28 July 2017

1 reference