The Relative Contribution of IL-4 Receptor Signaling and IL-10 to Susceptibility toLeishmania major (Q73361338)

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3 November 2019

title

The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major (English)

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3 November 2019

The Relative Contribution of IL-4 Receptor Signaling and IL-10 to Susceptibility toLeishmania major (English)

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31 December 2023

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genetic predisposition to disease

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author name string

Nancy Noben-Trauth

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3 November 2019

Rosalia Lira

2

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3 November 2019

Hisashi Nagase

3

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3 November 2019

William E. Paul

4

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David L. Sacks

5

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language of work or name

English

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publication date

1 May 2003

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3 November 2019

15 May 2003

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12734362

full work available at URL

31 December 2023

published in

Journal of Immunology

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3 November 2019

volume

170

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page(s)

5152-5158

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issue

10

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The immunology of susceptibility and resistance to Leishmania major in mice

3 November 2019

cites work

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

The regulation of immunity to Leishmania major

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

In susceptible mice, Leishmania major induce very rapid interleukin-4 production by CD4+ T cells which are NK1.1-

31 December 2023

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

Resistance to Leishmania major induced by tolerance to a single antigen

31 December 2023

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

IL-4 Rapidly Produced by Vβ4 Vα8 CD4+ T Cells Instructs Th2 Development and Susceptibility to Leishmania major in BALB/c Mice

31 December 2023

5

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism

31 December 2023

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

Cure of progressive murine leishmaniasis: interleukin 4 dominance is abolished by transient CD4(+) T cell depletion and T helper cell type 1-selective cytokine therapy

31 December 2023

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

Expression of Th2 cytokines and the stable Th2 marker ST2L in the absence of IL-4 during Leishmania major infection

31 December 2023

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

Interleukin-10 and the interleukin-10 receptor

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

The role of IL-10 in promoting disease progression in leishmaniasis

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An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.

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Interleukin-10-deficient mice develop chronic enterocolitis

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure.

31 December 2023

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

Interleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapy

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

IL-13 is a susceptibility factor for Leishmania major infection.

31 December 2023

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile

31 December 2023

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

Interleukin-4 receptor alpha-deficient BALB/c mice show an unimpaired T helper 2 polarization in response to Leishmania major infection

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

Conventional, naive CD4+ T cells provide an initial source of IL-4 during Th2 differentiation

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Stat6 regulation of in vivo IL-4 responses

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

31 December 2023

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

The early IL-4 response to Leishmania major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4+CD25+ T cells.

31 December 2023

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma

31 December 2023

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https://api.crossref.org/works/10.4049/JIMMUNOL.170.10.5152

Interleukin 10 production correlates with pathology in human Leishmania donovani infections

31 December 2023

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Splenic cytokine responses in Indian kala-azar before and after treatment

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High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis

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31 December 2023

Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12734362%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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