Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity (Q33247158)

24 July 2017

Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity (English)

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24 July 2017

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10

Christopher A Ross

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12

Lisa M Ellerby

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24 July 2017

Birgit Schilling

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Juliette Gafni

2

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Cameron Torcassi

3

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Xin Cong

4

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Richard H Row

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Michelle A LaFevre-Bernt

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Michael P Cusack

7

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Tamara Ratovitski

8

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Ricky Hirschhorn

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Bradford W Gibson

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24 July 2017

language of work or name

English

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publication date

16 June 2006

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Journal of Biological Chemistry

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281

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23686-23697

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33

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describes a project that uses

24 July 2017

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Huntingtin contains a highly conserved nuclear export signal

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

SUMO modification of Huntingtin and Huntington's disease pathology

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513507200

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Analysis of protein phosphorylation by hypothesis-driven multiple-stage mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Inducible PC12 cell model of Huntington's disease shows toxicity and decreased histone acetylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513507200

Automatic identification of proteins with a MALDI-quadrupole ion trap mass spectrometer.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Probability-based protein identification by searching sequence databases using mass spectrometry data

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

How do protein kinases recognize their substrates?

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Sequence and structure-based prediction of eukaryotic protein phosphorylation sites

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Identification of phosphorylation sites using microimmobilized metal affinity chromatography.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Are there multiple pathways in the pathogenesis of Huntington's disease?

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Nuclear targeting of mutant Huntingtin increases toxicity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Kennedy's disease. Phosphorylation of the polyglutamine-expanded form of androgen receptor regulates its cleavage by caspase-3 and enhances cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513507200

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513507200

A cell-based screen for modulators of ataxin-1 phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513507200

21 January 2018

Identifiers

DOI

10.1074/JBC.M513507200

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24 July 2017

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