Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner (Q33195730)

23 July 2017

Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner (English)

1 reference

23 July 2017

1 reference

Xiaohua Wu

1

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23 July 2017

Chad E N Reiter

2

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23 July 2017

David A Antonetti

3

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23 July 2017

Scot R Kimball

4

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23 July 2017

Leonard S Jefferson

5

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23 July 2017

Thomas W Gardner

6

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23 July 2017

language of work or name

English

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publication date

5 December 2003

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Journal of Biological Chemistry

23 July 2017

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23 July 2017

279

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23 July 2017

10

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23 July 2017

9167-9175

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New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets

23 July 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M312397200

The phosphoinositide 3-kinase pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M312397200

PI3K: downstream AKTion blocks apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Characterization of insulin signaling in rat retina in vivo and ex vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

The modular phosphorylation and activation of p70s6k.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Ribosomal S6 kinase signaling and the control of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Translation control: connecting mitogens and the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Using structure to define the function of phosphoinositide 3-kinase family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Intracellular signalling: PDK1--a kinase at the hub of things

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

TOR signalling and control of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Synthesis of the translational apparatus is regulated at the translational level

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

p70 S6 kinase: an enigma with variations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Phosphorylation and activation of p70s6k by PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

The akt kinase: molecular determinants of oncogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Atypical protein kinase Clambda binds and regulates p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Control of p70 s6 kinase by kinase activity of FRAP in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Effect of insulin-like growth factor II on protecting myoblast cells against cisplatin-induced apoptosis through p70 S6 kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Staurosporine inhibits phosphorylation of translational regulators linked to mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the phosphatidylinositol 3-kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Identification of a conserved motif required for mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

15-Deoxyspergualin inhibits Akt kinase activation and phosphatidylcholine synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Insulin and insulin-like growth factor system components gene expression in the chicken retina from early neurogenesis until late development and their effect on neuroepithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Gene expression of the insulin-like growth factors and their receptors in cultured human retinal pigment epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Insulin receptor substrate-1, p70S6K, and cell size in transformation and differentiation of hemopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Internal ribosome initiation of translation and the control of cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

The role of PI 3-kinase in insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312397200

21 January 2018

Identifiers

DOI

10.1074/JBC.M312397200

1 reference

23 July 2017

1 reference