Divergent label-free cell phenotypic pharmacology of ligands at the overexpressed β₂-adrenergic receptors (Q31148493)

13 October 2017

Divergent label-free cell phenotypic pharmacology of ligands at the overexpressed β₂-adrenergic receptors (English)

1 reference

13 October 2017

1 reference

1 reference

Ann M Ferrie

1

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13 October 2017

Haiyan Sun

series ordinal

2

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13 October 2017

Natalya Zaytseva

series ordinal

3

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13 October 2017

Ye Fang

series ordinal

4

1 reference

13 October 2017

language of work or name

English

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publication date

23 January 2014

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13 October 2017

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13 October 2017

4

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13 October 2017

3828

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Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

13 October 2017

start time

23 January 2014

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Dissociations in the effects of β2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: support for the concept of functional selectivity

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Efficacy and ligand bias at the μ-opioid receptor

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Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family

14 July 2018

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Signalling bias in new drug discovery: detection, quantification and therapeutic impact.

14 July 2018

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Molecular signatures of G-protein-coupled receptors

14 July 2018

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The dynamic process of β(2)-adrenergic receptor activation

14 July 2018

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Efficacy of the β₂-adrenergic receptor is determined by conformational equilibrium in the transmembrane region

14 July 2018

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The potential for selective pharmacological therapies through biased receptor signaling

14 July 2018

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Ligand-specific interactions modulate kinetic, energetic, and mechanical properties of the human β2 adrenergic receptor

14 July 2018

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Label-free integrative pharmacology on-target of drugs at the β(2)-adrenergic receptor

14 July 2018

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Recent progress in understanding of structure, ligand interactions and the mechanism of activation of the β₂-adrenergic receptor

14 July 2018

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Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

14 July 2018

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Impedance responses reveal β₂-adrenergic receptor signaling pluridimensionality and allow classification of ligands with distinct signaling profiles

14 July 2018

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Biased signalling and allosteric machines: new vistas and challenges for drug discovery

14 July 2018

1 reference

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GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis.

14 July 2018

1 reference

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Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target

14 July 2018

1 reference

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Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors

14 July 2018

1 reference

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Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX.

14 July 2018

1 reference

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Multiple ligand-specific conformations of the β2-adrenergic receptor

14 July 2018

1 reference

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Crystal structure of the β2 adrenergic receptor-Gs protein complex

14 July 2018

1 reference

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Agonist-directed desensitization of the β2-adrenergic receptor

14 July 2018

1 reference

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Label-Free Receptor Assays

14 July 2018

1 reference

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Energy landscapes as a tool to integrate GPCR structure, dynamics, and function

14 July 2018

1 reference

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Functional selectivity in adrenergic and angiotensin signaling systems

14 July 2018

1 reference

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Differential signaling of the endogenous agonists at the beta2-adrenergic receptor

14 July 2018

1 reference

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Signalling ballet in space and time

14 July 2018

1 reference

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Teaching old receptors new tricks: biasing seven-transmembrane receptors

14 July 2018

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Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

14 July 2018

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Ligand-directed signalling at beta-adrenoceptors

14 July 2018

1 reference

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The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function

14 July 2018

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Cellular assays as portals to seven-transmembrane receptor-based drug discovery

14 July 2018

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Direct spatial control of Epac1 by cyclic AMP.

14 July 2018

1 reference

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Duplexed label-free G protein--coupled receptor assays for high-throughput screening

14 July 2018

1 reference

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Epac mediates PACAP-dependent long-term depression in the hippocampus

14 July 2018

1 reference

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Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.

14 July 2018

1 reference

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On the fitting of binding data when receptor dimerization is suspected

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Label-free optical biosensor for ligand-directed functional selectivity acting on beta(2) adrenoceptor in living cells.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

beta-arrestin-biased agonism at the beta2-adrenergic receptor

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Both ligand- and cell-specific parameters control ligand agonism in a kinetic model of g protein-coupled receptor signaling

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

How many drug targets are there?

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Epac proteins: multi-purpose cAMP targets

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Resonant waveguide grating biosensor for living cell sensing.

14 July 2018

1 reference

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Comparison of two alpha1-adrenoceptor antagonists, naftopidil and tamsulosin hydrochloride, in the treatment of lower urinary tract symptoms with benign prostatic hyperplasia: a randomized crossover study

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Characteristics of dynamic mass redistribution of epidermal growth factor receptor signaling in living cells measured with label-free optical biosensors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Drug discovery: a historical perspective

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Cluster analysis and display of genome-wide expression patterns

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Receptor interactions of imidazolines. IX. Cirazoline is an alpha-1 adrenergic agonist and an alpha-2 adrenergic antagonist

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899747

The development of label-free cellular assays for drug discovery

14 July 2018

1 reference

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements.

21 January 2018

1 reference

Beta(2)-adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for G(s)/G(i) switching.

21 January 2018

1 reference

Troubleshooting and deconvoluting label-free cell phenotypic assays in drug discovery.

21 January 2018

1 reference

(1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24451999

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP03828

1 reference

Dimensions Publication ID

13 October 2017

0 references

1 reference

13 October 2017

1 reference