Projecting human pharmacokinetics of monoclonal antibodies from nonclinical data: comparative evaluation of prediction approaches in early drug development. (Q30930928)

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English	Projecting human pharmacokinetics of monoclonal antibodies from nonclinical data: comparative evaluation of prediction approaches in early drug development.	scientific article

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Projecting human pharmacokinetics of monoclonal antibodies from nonclinical data: comparative evaluation of prediction approaches in early drug development (English)

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based on heuristic

inferred from title

monoclonal antibody

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based on heuristic

inferred from title

pharmacokinetics

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based on heuristic

inferred from title

4

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author name string

Jing Wang

1

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Suhasini Iyer

2

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Paul J Fielder

3

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Rong Deng

5

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publication date

15 May 2015

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Biopharmaceutics and Drug Disposition

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37

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51-65

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2

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5 March 2020

Marketed therapeutic antibodies compendium

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Monoclonal antibodies: what are the pharmacokinetic and pharmacodynamic considerations for drug development?

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Animal scale-up

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Pharmacokinetic allometric scaling of antibodies: application to the first-in-human dose estimation

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Prediction of human plasma concentration-time profiles of monoclonal antibodies from monkey data by a species-invariant time method

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Mixed-effects modelling of the interspecies pharmacokinetic scaling of pegylated human erythropoietin

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Interspecies scaling of therapeutic monoclonal antibodies: initial look

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: what have we learned?

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Quantitative prediction of human pharmacokinetics for monoclonal antibodies: retrospective analysis of monkey as a single species for first-in-human prediction.

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Prediction of human pharmacokinetics of therapeutic monoclonal antibodies from simple allometry of monkey data

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

A model-based approach to predicting the human pharmacokinetics of a monoclonal antibody exhibiting target-mediated drug disposition

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Continuous cultures of fused cells secreting antibody of predefined specificity

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Antibody pharmacokinetics and pharmacodynamics

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Application of pharmacokinetics-pharmacodynamics/clinical response modeling and simulation for biologics drug development

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Population pharmacokinetics of therapeutic monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Clinical pharmacokinetics of therapeutic monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Finally! The Brambell receptor (FcRB). Mediator of transmission of immunity and protection from catabolism for IgG.

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

FcRn: the neonatal Fc receptor comes of age.

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

The origin of allometric scaling laws in biology from genomes to ecosystems: towards a quantitative unifying theory of biological structure and organization

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Interspecies pharmacokinetic scaling and the evolutionary-comparative paradigm

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Interspecies scaling of protein drugs: prediction of clearance from animals to humans

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences.

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Humanized FcRn mouse models for evaluating pharmacokinetics of human IgG antibodies

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Interspecies scaling: predicting pharmacokinetic parameters of antiepileptic drugs in humans from animals with special emphasis on clearance.

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

A mathematical description of the functionality of correction factors used in allometry for predicting human drug clearance.

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal Fc receptor (FcRn).

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Evaluation of a catenary PBPK model for predicting the in vivo disposition of mAbs engineered for high-affinity binding to FcRn

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Analysis of a family of antibodies with different half-lives in mice fails to find a correlation between affinity for FcRn and serum half-life

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Are endosomal trafficking parameters better targets for improving mAb pharmacokinetics than FcRn binding affinity?

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Pharmacologic target-mediated drug disposition

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Simultaneous Modeling of Abciximab Plasma Concentrations and ex Vivo Pharmacodynamics in Patients Undergoing Coronary Angioplasty

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Integrated cellular bone homeostasis model for denosumab pharmacodynamics in multiple myeloma patients

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Lessons for the clinic from rituximab pharmacokinetics and pharmacodynamics

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

General pharmacokinetic model for drugs exhibiting target-mediated drug disposition

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Selection between Michaelis-Menten and target-mediated drug disposition pharmacokinetic models

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Quasi-equilibrium pharmacokinetic model for drugs exhibiting target-mediated drug disposition.

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Target-mediated drug disposition model: approximations, identifiability of model parameters and applications to the population pharmacokinetic-pharmacodynamic modeling of biologics

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Approximations of the target-mediated drug disposition model and identifiability of model parameters.

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Scaling pharmacodynamics from in vitro and preclinical animal studies to humans

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Integrated pharmacokinetic-pharmacodynamic modeling and allometric scaling for optimizing the dosage regimen of the monoclonal ior EGF/r3 antibody.

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Interspecies scaling of receptor-mediated pharmacokinetics and pharmacodynamics of type I interferons

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

1 reference

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21 January 2018

A comprehensive review of the pharmacokinetics of approved therapeutic monoclonal antibodies in Japan: Are Japanese phase I studies still needed?

1 reference

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21 January 2018

Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4.

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Complex pharmacokinetics of a humanized antibody against human amyloid beta peptide, anti-abeta Ab2, in nonclinical species.

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1952

21 January 2018

Anti-neuropilin-1 (MNRP1685A): unexpected pharmacokinetic differences across species, from preclinical models to humans

1 reference

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21 January 2018

Effect of Target Dynamics on Pharmacokinetics of a Novel Therapeutic Antibody against the Epidermal Growth Factor Receptor: Implications for the Mechanisms of Action

1 reference

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21 January 2018

A Theoretical Model of γ-Globulin Catabolism

1 reference

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Identifiers

10.1002/BDD.1952

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Europe PubMed Central

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5 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25869767%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

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