Evaluation of a catenary PBPK model for predicting the in vivo disposition of mAbs engineered for high-affinity binding to FcRn (Q41931879)

14 October 2017

Evaluation of a catenary PBPK model for predicting the in vivo disposition of mAbs engineered for high-affinity binding to FcRn (English)

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14 October 2017

Yang Chen

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14 October 2017

Joseph P Balthasar

series ordinal

2

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14 October 2017

language of work or name

English

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publication date

7 September 2012

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14 October 2017

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14 October 2017

14

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14 October 2017

4

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14 October 2017

850-859

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https://scigraph.springernature.com/pub.10.1208/s12248-012-9395-9

14 October 2017

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A therapeutic anti-VEGF antibody with increased potency independent of pharmacokinetic half-life

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Enhanced antibody half-life improves in vivo activity

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Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice

5 June 2018

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Regulation of the V-ATPase along the endocytic pathway occurs through reversible subunit association and membrane localization

5 June 2018

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Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism

5 June 2018

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Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor

5 June 2018

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Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies

5 June 2018

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Analysis of a family of antibodies with different half-lives in mice fails to find a correlation between affinity for FcRn and serum half-life

5 June 2018

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Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn.

5 June 2018

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Engineered human IgG antibodies with longer serum half-lives in primates

5 June 2018

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Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences.

5 June 2018

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Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model

5 June 2018

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High-affinity binding of the neonatal Fc receptor to its IgG ligand requires receptor immobilization

5 June 2018

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Increasing the serum persistence of an IgG fragment by random mutagenesis.

5 June 2018

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Finally! The Brambell receptor (FcRB). Mediator of transmission of immunity and protection from catabolism for IgG.

5 June 2018

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A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus

5 June 2018

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Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model

5 June 2018

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Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells

5 June 2018

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Kinetics of endosome acidification in mutant and wild-type Chinese hamster ovary cells

5 June 2018

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Mediation of pinocytosis in cultured arterial smooth muscle and endothelial cells by platelet-derived growth factor

5 June 2018

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Marketed therapeutic antibodies compendium

5 June 2018

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Reduced elimination of IgG antibodies by engineering the variable region.

18 August 2018

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Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR.

18 August 2018

1 reference

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Development trends for therapeutic antibody fragments.

18 August 2018

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Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

18 August 2018

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Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates.

18 August 2018

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Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

18 August 2018

1 reference

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An engineered human IgG1 antibody with longer serum half-life.

18 August 2018

1 reference

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A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal Fc receptor (FcRn).

18 August 2018

1 reference

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Effects of mycophenolic acid (MPA) treatment on expression of Fc receptor (FcRn) and polymeric immunoglobulin receptor (pIgR) mRNA in adult sheep tissues

18 August 2018

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Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice.

18 August 2018

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Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy.

18 August 2018

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Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475865

Analysis of the pH dependence of the neonatal Fc receptor/immunoglobulin G interaction using antibody and receptor variants.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475865

Monoclonal antibody pharmacokinetics and pharmacodynamics

18 August 2018

1 reference

12 December 2020

Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates

1 reference

12 December 2020

Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys

1 reference

12 December 2020

Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans

1 reference

12 December 2020

Enhanced rates of fluid pinocytosis during exponential growth and monolayer regeneration by cultured arterial endothelial cells

1 reference

12 December 2020

Pharmacokinetics of monoclonal immunoglobulin G1, F(ab')2, and Fab' in mice

1 reference

12 December 2020

Cloning and expression of the neonatal rat intestinal Fc receptor, a major histocompatibility complex class I antigen homolog

1 reference

12 December 2020

Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice

1 reference

12 December 2020

Tumor development under angiogenic signaling: a dynamical theory of tumor growth, treatment response, and postvascular dormancy

1 reference

12 December 2020

FcRn mediates elongated serum half-life of human IgG in cattle

1 reference

12 December 2020

Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice

1 reference

12 December 2020

10.1208/S12248-012-9395-9

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14 October 2017

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14 October 2017

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