The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors (Q30486738)

20 August 2017

The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors (English)

1 reference

20 August 2017

1 reference

1

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5 June 2020

Elena Faccenda

3

1 reference

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5 June 2020

Adam J Pawson

4

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5 June 2020

Joanna L. Sharman

5

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5 June 2020

Michael Spedding

6

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5 June 2020

author name string

Helen E Benson

2

1 reference

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5 June 2020

John A Peters

7

1 reference

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5 June 2020

Anthony J Harmar

8

1 reference

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5 June 2020

CGTP Collaborators

9

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5 June 2020

language of work or name

English

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publication date

1 December 2013

1 reference

British Journal of Pharmacology

20 August 2017

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5 June 2020

volume

170

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5 June 2020

issue

8

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5 June 2020

page(s)

1652-1675

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TO901317, a potent LXR agonist, is an inverse agonist of CAR.

5 June 2020

cites work

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20 June 2018

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20 June 2018

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Mechanisms of thyroid hormone action

20 June 2018

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HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter

20 June 2018

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PPAR-γ as a therapeutic target in cardiovascular disease: evidence and uncertainty

20 June 2018

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FXR signaling in the enterohepatic system

20 June 2018

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Pregnane X receptor as a target for treatment of inflammatory bowel disorders

20 June 2018

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Molecular pathways: the role of NR4A orphan nuclear receptors in cancer.

20 June 2018

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Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.

20 June 2018

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The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention

20 June 2018

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Therapeutic potential of Liver Receptor Homolog-1 modulators

20 June 2018

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Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

20 June 2018

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Constitutive androstane receptor (CAR) is a xenosensor and target for therapy

20 June 2018

1 reference

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Minireview: cracking the metabolic code for thyroid hormone signaling

20 June 2018

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Steroidogenic factor 1 and the central nervous system.

20 June 2018

1 reference

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Ligand-independent actions of the orphan receptors/corepressors DAX-1 and SHP in metabolism, reproduction and disease

20 June 2018

1 reference

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Unraveling the mechanisms underlying the rapid vascular effects of steroids: sorting out the receptors and the pathways.

20 June 2018

1 reference

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Modulation of RXR function through ligand design

20 June 2018

1 reference

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Thyromimetics: a journey from bench to bed-side

20 June 2018

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Peroxisome proliferator-activated receptors and cancer: challenges and opportunities

20 June 2018

1 reference

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Proteomics for the discovery of nuclear bile acid receptor FXR targets

20 June 2018

1 reference

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Inflammation: a role for NR4A orphan nuclear receptors?

20 June 2018

1 reference

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PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation

20 June 2018

1 reference

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Liver X receptors, lipids and their reproductive secrets in the male.

20 June 2018

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Nuclear receptor PXR, transcriptional circuits and metabolic relevance

20 June 2018

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NR4All in the vessel wall

20 June 2018

1 reference

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Coup d'Etat: an orphan takes control.

20 June 2018

1 reference

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Vitamin D: an ancient hormone

20 June 2018

1 reference

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The thyroid hormones and their nuclear receptors in the gut: from developmental biology to cancer

20 June 2018

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Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease

20 June 2018

1 reference

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Role of thyroid receptor β in lipid metabolism

20 June 2018

1 reference

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Emerging actions of the nuclear receptor LRH-1 in the gut.

20 June 2018

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Liver X receptors as regulators of macrophage inflammatory and metabolic pathways

20 June 2018

1 reference

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Functional and physiological genomics of estrogen-related receptors (ERRs) in health and disease

20 June 2018

1 reference

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Nuclear bile acid receptor FXR in the hepatic regeneration

20 June 2018

1 reference

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Role of DAX-1 (NR0B1) and steroidogenic factor-1 (NR5A1) in human adrenal function

20 June 2018

1 reference

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Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications

20 June 2018

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20 June 2018

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Vitamin D, disease and therapeutic opportunities

20 June 2018

1 reference

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The role of the orphan receptor SF-1 in the development and function of the ovary.

20 June 2018

1 reference

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Steroidogenic factor-1 (SF-1, NR5A1) and human disease

20 June 2018

1 reference

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The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor

20 June 2018

1 reference

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The molecular physiology of nuclear retinoic acid receptors. From health to disease

20 June 2018

1 reference

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Role of nuclear receptor SHP in metabolism and cancer

20 June 2018

1 reference

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Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D.

20 June 2018

1 reference

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HNF4α--role in drug metabolism and potential drug target?

20 June 2018

1 reference

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Glucocorticoid receptor cofactors as therapeutic targets

20 June 2018

1 reference

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GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.

20 June 2018

1 reference

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Retinoid X receptors: common heterodimerization partners with distinct functions

20 June 2018

1 reference

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NR4A orphan nuclear receptors: transcriptional regulators of gene expression in metabolism and vascular biology

20 June 2018

1 reference

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A role of the bile salt receptor FXR in atherosclerosis

20 June 2018

1 reference

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Liver x receptor signaling pathways and atherosclerosis

20 June 2018

1 reference

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What are nuclear receptor ligands?

20 June 2018

1 reference

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Structure of Rev-erbα bound to N-CoR reveals a unique mechanism of nuclear receptor–co-repressor interaction

20 June 2018

1 reference

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Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism

20 June 2018

1 reference

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Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease

20 June 2018

1 reference

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Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease.

20 June 2018

1 reference

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Aldosterone: effects on the kidney and cardiovascular system

20 June 2018

1 reference

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Minireview: steroidogenic factor 1: its roles in differentiation, development, and disease

20 June 2018

1 reference

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Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics

20 June 2018

1 reference

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FXR an emerging therapeutic target for the treatment of atherosclerosis

20 June 2018

1 reference

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Sex steroids and the male skeleton: a tale of two hormones

20 June 2018

1 reference

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The yin and yang of vitamin D receptor (VDR) signaling in neoplastic progression: operational networks and tissue-specific growth control

20 June 2018

1 reference

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Rev-erb-alpha: an integrator of circadian rhythms and metabolism

20 June 2018

1 reference

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Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists

20 June 2018

1 reference

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Identification of an endogenous ligand bound to a native orphan nuclear receptor

20 June 2018

1 reference

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Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit

20 June 2018

1 reference

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Estrogen-induced plasticity from cells to circuits: predictions for cognitive function

20 June 2018

1 reference

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Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease

20 June 2018

1 reference

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PPARs Mediate Lipid Signaling in Inflammation and Cancer

20 June 2018

1 reference

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Progesterone and progestins: neuroprotection and myelin repair

20 June 2018

1 reference

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Androgen receptor knockout and knock-in mouse models.

20 June 2018

1 reference

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Structure-function relationships in the mineralocorticoid receptor

20 June 2018

1 reference

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Tissue-specific glucocorticoid action: a family affair

20 June 2018

1 reference

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Rapid signaling by steroid receptors

20 June 2018

1 reference

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Cytosporone B is an agonist for nuclear orphan receptor Nur77.

20 June 2018

1 reference

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Targeting the androgen receptor pathway in prostate cancer

20 June 2018

1 reference

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Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors

20 June 2018

1 reference

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Indirect androgen doping by oestrogen blockade in sports

20 June 2018

1 reference

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Progesterone and progestin receptors in the brain: the neglected ones

20 June 2018

1 reference

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Androgen receptor functions in male and female physiology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening

20 June 2018

1 reference

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Mineralocorticoid receptors in brain, in health and disease: possibilities for new pharmacotherapy

20 June 2018

1 reference

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Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.

20 June 2018

1 reference

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The coming out of the brain mineralocorticoid receptor.

20 June 2018

1 reference

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Identification of the first synthetic steroidogenic factor 1 inverse agonists: pharmacological modulation of steroidogenic enzymes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Molecular basis of endocrine regulation by orphan nuclear receptor Small Heterodimer Partner

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Retinoic acid in the development, regeneration and maintenance of the nervous system

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Estrogen receptor beta in the brain: from form to function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Protein kinases and the proteasome join in the combinatorial control of transcription by nuclear retinoic acid receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Drug insight: role of the androgen receptor in the development and progression of prostate cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

International Union of Pharmacology. LXVI. Orphan nuclear receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

International Union of Pharmacology. LXIV. Estrogen receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

International Union of Pharmacology. LXIII. Retinoid X receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D recept

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

International Union of Pharmacology. LX. Retinoic acid receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

International Union of Pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Overview of nomenclature of nuclear receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Biological activities of a novel selective oestrogen receptor modulator derived from raloxifene (Y134).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Acute effects of estrogen on neuronal physiology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Integrin alphaVbeta3 contains a cell surface receptor site for thyroid hormone that is linked to activation of mitogen-activated protein kinase and induction of angiogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Identification of an agonist ligand for estrogen-related receptors ERRbeta/gamma.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

MK-0767, a novel dual PPARalpha/gamma agonist, displays robust antihyperglycemic and hypolipidemic activities

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Classification and pharmacology of progestins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Identification of natural ligands of retinoic acid receptor-related orphan receptor α ligand-binding domain expressed in Sf9 cells––a mass spectrometry approach

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Expression of the transcription factor, tailless, is required for formation of superficial cortical layers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Peroxisome proliferator-activated receptors: a critical review on endogenous pathways for ligand generation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Spermatogenesis and testis development are normal in mice lacking testicular orphan nuclear receptor 2

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Bisphenol a diglycidyl ether (BADGE) suppresses tumor necrosis factor-alpha production as a PPARgamma agonist in the murine macrophage-like cell line, RAW 264.7.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Carboxylic ester antagonists of 1alpha,25-dihydroxyvitamin D(3) show cell-specific actions.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Bisphenol A diglycidyl ether (BADGE) is a PPARgamma agonist in an ECV304 cell line

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

St John's wort, a herbal antidepressant, activates the steroid X receptor.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Identification of a chemical tool for the orphan nuclear receptor FXR.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Preserved male fertility despite decreased androgen sensitivity caused by a mutation in the ligand-binding domain of the androgen receptor gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Retinoid X receptor-antagonistic diazepinylbenzoic acids

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

The PPARs: from orphan receptors to drug discovery

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Therapeutic applications for ligands of retinoid receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Specific hydroxylations determine selective corticosteroid recognition by human glucocorticoid and mineralocorticoid receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl- 5,6,11, 12-tetrahydrochrysenes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Bile acids: natural ligands for an orphan nuclear receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Identification of a nuclear receptor for bile acids

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Androgen antagonistic effect of estramustine phosphate (EMP) metabolites on wild-type and mutated androgen receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

The antagonists RU486 and ZK98299 stimulate progesterone receptor binding to deoxyribonucleic acid in vitro and in vivo, but have distinct effects on receptor conformation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Defective limbic system in mice lacking the tailless gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Comparison of in vitro effects of the pure antiandrogens OH-flutamide, Casodex, and nilutamide on androgen-sensitive parameters

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

A decade of molecular biology of retinoic acid receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Studies on two new vitamin D analogs, EB 1089 and KH 1060: effects on bone resorption and osteoclast recruitment in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

The RXR heterodimers and orphan receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Profile of ligand specificity of the vitamin D binding protein for 1 alpha,25-dihydroxyvitamin D3 and its analogs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Plasma concentrations and receptor binding of RU 486 and its metabolites in humans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Characterization and expression of a cDNA encoding the human androgen receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Selective high affinity retinoic acid receptor alpha or beta-gamma ligands

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

EB1089: a new vitamin D analogue that inhibits the growth of breast cancer cells in vivo and in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Selective Synthetic Ligands for Human Nuclear Retinoic Acid Receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Opiate-dependent modulation of adenylate cyclase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment

20 June 2018

1 reference

Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist

21 January 2018

1 reference

Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis

21 January 2018

1 reference

The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice

21 January 2018

1 reference

A novel peroxisome proliferator-activated receptor alpha/gamma dual agonist demonstrates favorable effects on lipid homeostasis

21 January 2018

1 reference

Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo

21 January 2018

1 reference

Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.

21 January 2018

1 reference

Design and synthesis of potent vitamin D receptor antagonists with A-ring modifications: remarkable effects of 2alpha-methyl introduction on antagonistic activity

21 January 2018

1 reference

Co-regulator recruitment and the mechanism of retinoic acid receptor synergy

21 January 2018

1 reference

Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma

21 January 2018

1 reference

Structural basis for the cell-specific activities of the NGFI-B and the Nurr1 ligand-binding domain

21 January 2018

1 reference

Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications.

21 January 2018

1 reference

Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues

21 January 2018

1 reference

Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists.

21 January 2018

1 reference

The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Antagonists selective for estrogen receptor alpha

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-alpha and estrogen receptor-beta: correlations with biological character and distinct differences among SRC coactivator family members

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Agonist and antagonists induce homodimerization and mixed ligand heterodimerization of human progesterone receptors in vivo by a mammalian two-hybrid assay.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Extravascular CBG-like sites in rat kidney and mineralocorticoid receptor specificity

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892290

Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro

26 November 2018

1 reference

12 December 2020

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

1 reference

12 December 2020

Non-genomic signaling by steroids

1 reference

12 December 2020

Structure and function of cytoplasmic retinoid binding proteins

1 reference

12 December 2020

Antagonistic action of novel 1alpha,25-dihydroxyvitamin D3-26, 23-lactone analogs on differentiation of human leukemia cells (HL-60) induced by 1alpha,25-dihydroxyvitamin D3

1 reference

12 December 2020

Identifiers

DOI

10.1111/BPH.12448

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24528240%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24528240%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24528240%20AND%20SRC:MED&resulttype=core&format=json