Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion (Q30447828)

13 August 2017

Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion (English)

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13 August 2017

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Solomon Halbert Snyder

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object named as

S H Snyder

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T M Ma

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S Abazyan

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B Abazyan

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J Nomura

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C Yang

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S Seshadri

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A Sawa

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M V Pletnikov

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language of work or name

English

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publication date

17 July 2012

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557-567

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describes a project that uses

13 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3475769/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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DISC1 at 10: connecting psychiatric genetics and neuroscience

28 July 2018

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Contributions of the D-serine pathway to schizophrenia.

28 July 2018

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Serine racemase and the serine shuttle between neurons and astrocytes

28 July 2018

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Serine racemase knockout mice

28 July 2018

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High dose D-serine in the treatment of schizophrenia

28 July 2018

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Neuronal release of D-serine: a physiological pathway controlling extracellular D-serine concentration

28 July 2018

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The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain

28 July 2018

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Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade

28 July 2018

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Long-term potentiation depends on release of D-serine from astrocytes

28 July 2018

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Death-associated protein kinase-mediated cell death modulated by interaction with DANGER

28 July 2018

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Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders.

28 July 2018

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Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1.

28 July 2018

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Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine racemase to the membrane

28 July 2018

1 reference

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Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior

28 July 2018

1 reference

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Serine racemase is predominantly localized in neurons in mouse brain

28 July 2018

1 reference

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Neuron-astrocyte signaling in the development and plasticity of neural circuits

28 July 2018

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Schizophrenia candidate genes: are we really coming up blank?

28 July 2018

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Modulation of D-serine levels in brains of mice lacking PICK1

28 July 2018

1 reference

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A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function

28 July 2018

1 reference

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Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice

28 July 2018

1 reference

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Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans

28 July 2018

1 reference

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Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation

28 July 2018

1 reference

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Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia

28 July 2018

1 reference

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A CSF and postmortem brain study of D-serine metabolic parameters in schizophrenia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

A genetic variant of the serine racemase gene is associated with schizophrenia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

Changes in D-serine levels and localization during postnatal development of the rat vestibular nuclei

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

Modulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

Glia-derived D-serine controls NMDA receptor activity and synaptic memory

28 July 2018

1 reference

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Neuron-derived D-serine release provides a novel means to activate N-methyl-D-aspartate receptors.

28 July 2018

1 reference

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Immunocytochemical analysis of D-serine distribution in the mammalian brain reveals novel anatomical compartmentalizations in glia and neurons

28 July 2018

1 reference

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Serine racemase binds to PICK1: potential relevance to schizophrenia

28 July 2018

1 reference

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A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development

28 July 2018

1 reference

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Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels

28 July 2018

1 reference

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D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia

28 July 2018

1 reference

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Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

DISC1 (Disrupted in Schizophrenia-1) is expressed in limbic regions of the primate brain.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

Schizophrenia: neural mechanisms for novel therapies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

The emerging role of glutamate in the pathophysiology and treatment of schizophrenia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

Disruption of two novel genes by a translocation co-segregating with schizophrenia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

D-serine added to antipsychotics for the treatment of schizophrenia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

The psychopharmacology of astroglial cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

Association within a family of a balanced autosomal translocation with major mental illness

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

Recent advances in the phencyclidine model of schizophrenia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology

28 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Human serine racemase: moleular cloning, genomic organization and functional analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Behavioral phenotypes of Disc1 missense mutations in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Neuron-glia interactions clarify genetic-environmental links in mental illness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Induction of secretory phospholipase A2 in reactive astrocytes in response to transient focal cerebral ischemia in the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Glycine and D: -serine, but not D: -cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Epidemiology-driven neurodevelopmental animal models of schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase (Phgdh) and neutral amino acid transporter ASCT1 following an excitotoxic lesion in the mouse hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

A critique of the dopamine hypothesis of schizophrenia and psychosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Serine racemase deletion abolishes light-evoked NMDA receptor currents in retinal ganglion cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.97

Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

D-serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

Behavioral approaches to the functional assessment of NMDA-mediated neural transmission in intact mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

D-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475769

Endogenous D-serine contributes to NMDA-receptor-mediated light-evoked responses in the vertebrate retina

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22801410

12 December 2020

inferred from PubMed ID database lookup

Determination of free amino acid enantiomers in rat brain and serum by high-performance liquid chromatography after derivatization with N-tert.-butyloxycarbonyl-L-cysteine and o-phthaldialdehyde

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22801410

12 December 2020

inferred from PubMed ID database lookup

Glycine and D-serine decrease MK-801-induced hyperactivity in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22801410

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/MP.2012.97

1 reference

Dimensions Publication ID

13 August 2017

0 references

1 reference

13 August 2017

1 reference