N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement. (Q30427199)

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English	N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.	scientific article

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7 March 2020

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement (English)

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Karen J. Gregory

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Alexis S Hammond

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Wilhelmus Drinkenburg

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M G Caron

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E J Herman

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N E Byun

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S R Stauffer

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J T Manka

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S Jadhav

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T M Bridges

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C D Weaver

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C M Niswender

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T Steckler

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A Ahnaou

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H Lavreysen

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G J Macdonald

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J M Bartolomé

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C Mackie

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B J Hrupka

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T L Daigle

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C W Lindsley

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P J Conn

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C K Jones

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21 August 2013

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Journal of Pharmacology and Experimental Therapeutics

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7 March 2020

Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology

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Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity

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Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity

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Metabotropic glutamate receptors for new treatments in schizophrenia

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Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5

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4-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators

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Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia

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A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators

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A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

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Mice with reduced NMDA receptor expression display behaviors related to schizophrenia

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The mGlu₅ positive allosteric modulator LSN2463359 differentially modulates motor, instrumental and cognitive effects of NMDA receptor antagonists in the rat.

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Effects of NMDA receptor antagonists: implications for the pathophysiology of schizophrenia

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Effect of novel atypical antipsychotic, blonanserin, on extracellular neurotransmitter level in rat prefrontal cortex

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12 December 2020

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Identifiers

10.1124/JPET.113.206623

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7 March 2020

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7 March 2020

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7 March 2020

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