A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling (Q36717066)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23348500%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling (English)

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22 February 2020

1 reference

2

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22 February 2020

author name string

M J Noetzel

1

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22 February 2020

P N Vinson

3

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22 February 2020

J T Manka

4

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22 February 2020

S R Stauffer

5

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22 February 2020

C W Lindsley

6

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22 February 2020

C M Niswender

7

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22 February 2020

Z Xiang

8

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22 February 2020

P J Conn

9

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22 February 2020

publication date

24 January 2013

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22 February 2020

published in

Molecular Pharmacology

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22 February 2020

volume

83

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22 February 2020

page(s)

835-847

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22 February 2020

issue

4

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Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome

22 February 2020

cites work

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Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships

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Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.

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Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists

30 September 2017

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Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology

30 September 2017

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Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

30 September 2017

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Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential

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Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7

30 September 2017

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Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines

30 September 2017

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mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

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ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activiti

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Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells

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A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors

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N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors

30 September 2017

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30 September 2017

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30 September 2017

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A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators

30 September 2017

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30 September 2017

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A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain

30 September 2017

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Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.

30 September 2017

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Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.

30 September 2017

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

30 September 2017

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Quantitative analysis reveals multiple mechanisms of allosteric modulation of the mGlu5 receptor in rat astroglia

30 September 2017

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Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).

28 June 2018

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Involvement of the metabotropic glutamate receptor mGluR5 in NMDA receptor-dependent, learning-facilitated long-term depression in CA1 synapses

28 June 2018

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Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes

28 June 2018

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Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.

28 June 2018

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Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors.

28 June 2018

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Phosphorylation of mitogen-activated protein kinase in cultured rat cortical glia by stimulation of metabotropic glutamate receptors.

28 June 2018

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5 September 2018

Identifiers

DOI

10.1124/MOL.112.082891

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23348500%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23348500%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

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