Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information. (Q30322978)

18 June 2017

Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information. (English)

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18 June 2017

Ruas M

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18 June 2017

Brookes S

series ordinal

2

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18 June 2017

McDonald NQ

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3

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18 June 2017

Peters G

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4

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18 June 2017

language of work or name

English

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publication date

1 September 1999

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18 June 2017

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18 June 2017

18

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18 June 2017

39

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18 June 2017

5423-5434

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

18 June 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Point mutations can inactivate in vitro and in vivo activities of p16(INK4a)/CDKN2A in human glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Structural characterization of the tumor suppressor p16, an ankyrin-like repeat protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Restoration of CDKN2A into melanoma cells induces morphologic changes and reduction in growth rate but not anchorage-independent growth reversal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Biochemical characterization of p16INK4- and p18-containing complexes in human cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Expression of p16 induces transcriptional downregulation of the RB gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Analysis of the CDKN2A, CDKN2B and CDK4 genes in 48 Australian melanoma kindreds

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

High frequency of chromosome 9p allelic loss and CDKN2 tumor suppressor gene alterations in squamous cell carcinoma of the bladder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Germline Mutations of the CDKN2 Gene in UK Melanoma Families

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK4l (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Germline p16 mutations in familial melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Cancer-susceptibility genes. Gatekeepers and caretakers

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Mutational analysis of CDKN2 (CDK4I/MTS1) gene in tissues and cell lines of human prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Cancer-associated mis-sense and deletion mutations impair p16INK4 CDK inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Structure of the cyclin-dependent kinase inhibitor p19Ink4d

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Alterations of P16 (MTS1) in node-positive non-small cell lung carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Mechanisms of cyclin-dependent kinase inactivation by progestins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Mutations and altered expression of p16INK4 in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Production of high-titer helper-free retroviruses by transient transfection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Mutations associated with familial melanoma impair p16INK4 function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

G1 phase progression: cycling on cue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Inhibitors of mammalian G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group [published erratum appears in Hum Mol Genet 1998 May;7(5):941]

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Suppression of growth in vitro and tumorigenicity in vivo of human carcinoma cell lines by transfected p16INK4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

p16 mutations/deletions are not frequent events in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Tumor suppressor p16INK4A: structural characterization of wild-type and mutant proteins by NMR and circular dichroism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Induction of senescence in human malignant glioma cells by p16INK4A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

The retinoblastoma protein and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Brief report: a familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Overcoming cellular senescence in human cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

G1 control gene status is frequently altered in resectable non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

7 January 2021

The current situation with regard to human melanoma and genetic inferences.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

7 January 2021

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

7 January 2021

Ankyrin for clues about the function of p16INK4a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

7 January 2021

Alterations of the p16 gene in head and neck cancer: frequency and association with p53, PRAD-1 and HPV

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

7 January 2021

Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

7 January 2021

The p16INK4a/CDKN2A tumor suppressor and its relatives.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

7 January 2021

CDKN2A mutation in a non-FAMMM kindred with cancers at multiple sites results in a functionally abnormal protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

7 January 2021

Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

7 January 2021

Familial tumor syndrome associated with a germline nonfunctional p16INK4a allele

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202918

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1202918

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Dimensions Publication ID

18 June 2017

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1 reference