Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d (Q27765359)

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4 December 2019

title

Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d (English)

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4 December 2019

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3

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Brian O. Smith

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Manuel Serrano

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Ernest D. Laue

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Blundell TL

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4 December 2019

author name string

Brotherton DH

1

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Dhanaraj V

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Brizuela L

4

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Domaille PJ

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Volyanik E

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Xu X

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Parisini E

8

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Archer SJ

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Brenner SL

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language of work or name

English

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publication date

1 September 1998

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4 December 2019

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volume

395

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page(s)

244-250

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4 December 2019

issue

6699

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4 December 2019

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Principles of CDK regulation

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The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system

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Inhibitors of mammalian G1 cyclin-dependent kinases

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Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

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Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

1 reference

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Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4

1 reference

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Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4

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The retinoblastoma protein and cell cycle control

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Crystal structure of cyclin-dependent kinase 2

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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

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Structural basis of cyclin-dependent kinase activation by phosphorylation

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Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally?

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Structure of the cyclin-dependent kinase inhibitor p19Ink4d

1 reference

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Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations

1 reference

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Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4

1 reference

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The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2

1 reference

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Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

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The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA

1 reference

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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

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Identification of CDK4 sequences involved in cyclin D1 and p16 binding

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Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

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Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group [published erratum appears in Hum Mol Genet 1998 May;7(5):941]

1 reference

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Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

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Three protein kinase structures define a common motif

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Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor

1 reference

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Biochemical characterization of p16INK4- and p18-containing complexes in human cell lines

1 reference

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Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

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Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

1 reference

7 January 2021

Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells

1 reference

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Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

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Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

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7 January 2021

Refinement of macromolecular structures by the maximum-likelihood method

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Improved Fourier coefficients for maps using phases from partial structures with errors

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Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

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Raster3D Version 2.0. A program for photorealistic molecular graphics

1 reference

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The CDKN2A (p16) gene and human cancer.

1 reference

7 January 2021

Identifiers

DOI

10.1038/26164

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9751051%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

4 December 2019

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