Mechanism and function of Vav1 localisation in TCR signalling. (Q30010016)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956543%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Mechanism and function of Vav1 localisation in TCR signalling (English)

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12 February 2020

3

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12 February 2020

Katrin Rittinger

8

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12 February 2020

Victor Tybulewicz

10

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12 February 2020

4

Jonathan Rapley

1 reference

12 February 2020

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1

Olga Ksionda

1 reference

12 February 2020

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Alexander Saveliev

2

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12 February 2020

Mustapha Faroudi

5

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12 February 2020

Jennifer E Smith-Garvin

6

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12 February 2020

Christoph Wülfing

7

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12 February 2020

Tom Carter

9

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12 February 2020

language of work or name

English

0 references

publication date

6 September 2012

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12 February 2020

published in

Journal of Cell Science

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12 February 2020

volume

125

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12 February 2020

page(s)

5302-5314

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12 February 2020

issue

Pt 22

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Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

12 February 2020

copyright license

start time

4 September 2020

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3561853/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Cooperative interactions at the SLP-76 complex are critical for actin polymerization

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Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

22 May 2017

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Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1

22 May 2017

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Crucial structural role for the PH and C1 domains of the Vav1 exchange factor

22 May 2017

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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

22 May 2017

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SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond

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Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains

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Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

22 May 2017

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Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways

22 May 2017

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Novel recognition mode between Vav and Grb2 SH3 domains

22 May 2017

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Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

22 May 2017

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Plat-E: an efficient and stable system for transient packaging of retroviruses

22 May 2017

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Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade

22 May 2017

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The immunological synapse: a molecular machine controlling T cell activation

22 May 2017

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SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity

22 May 2017

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Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-gamma1 and phosphoinositide 3-kinase during granulocytic differentiation of HL-60 cells

22 May 2017

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A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts

22 May 2017

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Three-dimensional segregation of supramolecular activation clusters in T cells

22 May 2017

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LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation

22 May 2017

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Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

22 May 2017

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Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

22 May 2017

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p95vav associates with the nuclear protein Ku-70

22 May 2017

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The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav

22 May 2017

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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

22 May 2017

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Itk controls the spatiotemporal organization of T cell activation

22 May 2017

1 reference

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Vav1-mediated scaffolding interactions stabilize SLP-76 microclusters and contribute to antigen-dependent T cell responses

3 June 2018

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Understanding the structure and function of the immunological synapse

3 June 2018

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A revised model for the secretion of tPA and cytokines from cultured endothelial cells

3 June 2018

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Function of the nucleotide exchange activity of vav1 in T cell development and activation

3 June 2018

1 reference

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Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain

3 June 2018

1 reference

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The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse

3 June 2018

1 reference

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Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: role of Vav1 in modulating PU.1-containing complexes during ATRA-induced differentiation.

3 June 2018

1 reference

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Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity

3 June 2018

1 reference

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Spatiotemporal patterning during T cell activation is highly diverse

3 June 2018

1 reference

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Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation

3 June 2018

1 reference

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Persistence of cooperatively stabilized signaling clusters drives T-cell activation

3 June 2018

1 reference

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CD28 costimulatory signal induces protein arginine methylation in T cells.

3 June 2018

1 reference

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Vav-family proteins in T-cell signalling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Visualizing single molecules inside living cells using total internal reflection fluorescence microscopy.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Vav1 is a component of transcriptionally active complexes.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Membrane compartmentation is required for efficient T cell activation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Vav binding to heterogeneous nuclear ribonucleoprotein (hnRNP) C. Evidence for Vav-hnRNP interactions in an RNA-dependent manner.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

CD28 signal transduction pathways. A comparison of B7-1 and B7-2 regulation of the map kinases: ERK2 and Jun kinases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Vav is necessary for prolactin-stimulated proliferation and is translocated into the nucleus of a T-cell line

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Altered TCR signaling from geometrically repatterned immunological synapses.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Vav1 Transduces T Cell Receptor Signals to the Activation of the Ras/ERK Pathway via LAT, Sos, and RasGRP1

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

The immunological synapse of CTL contains a secretory domain and membrane bridges.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

CD28 utilizes Vav-1 to enhance TCR-proximal signaling and NF-AT activation.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561853

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

26 November 2018

1 reference

12 December 2020

Age-dependent alterations in the assembly of signal transduction complexes at the site of T cell/APC interaction

1 reference

12 December 2020

CD28 Signaling via VAV/SLP-76 Adaptors

1 reference

12 December 2020

Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse

1 reference

12 December 2020

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1 reference

12 December 2020

Identifiers

DOI

10.1242/JCS.105148

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956543%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956543%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956543%20AND%20SRC:MED&resulttype=core&format=json