The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity (Q24293101)

Ribosomal protein S6 kinase B2

GOA release 2020-03-11

1 reference

positive regulation of translational initiation

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Nahum Sonenberg

10

0 references

Virginie Mieulet

3

object named as

Virginie Mieulet

0 references

Philippe P. Roux

object named as

Philippe P Roux

2

0 references

author name string

David Shahbazian

1

0 references

Michael S Cohen

4

0 references

Brian Raught

5

0 references

Jack Taunton

6

0 references

John W B Hershey

7

0 references

John Blenis

8

0 references

Mario Pende

A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay

9

0 references

language of work or name

English

0 references

publication date

21 June 2006

0 references

published in

The EMBO Journal

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volume

25

0 references

page(s)

2781-91

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issue

12

0 references

cites work

1 reference

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PDK1, the master regulator of AGC kinase signal transduction

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Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

19 March 2017

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S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

19 March 2017

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Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation

19 March 2017

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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Mechanism of activation of protein kinase B by insulin and IGF-1

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A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3

19 March 2017

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Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

19 March 2017

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Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A

19 March 2017

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eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

19 March 2017

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90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

19 March 2017

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A 110-kilodalton subunit of translation initiation factor eIF3 and an associated 135-kilodalton protein are encoded by the Saccharomyces cerevisiae TIF32 and TIF31 genes

19 March 2017

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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

19 March 2017

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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

19 March 2017

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Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin

19 March 2017

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The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

19 March 2017

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Two structural domains of initiation factor eIF-4B are involved in binding to RNA

19 March 2017

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ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

19 March 2017

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Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F

7 April 2017

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Structural bioinformatics-based design of selective, irreversible kinase inhibitors

7 April 2017

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Recent advances in the regulation of the TOR pathway by insulin and nutrients

27 September 2017

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Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT

27 September 2017

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Signaling control of mRNA translation in cancer pathogenesis

27 September 2017

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Assembly of 48S translation initiation complexes from purified components with mRNAs that have some base pairing within their 5' untranslated regions.

27 September 2017

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In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

27 September 2017

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Role of S6 phosphorylation and S6 kinase in cell growth

27 September 2017

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Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

27 September 2017

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A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

27 September 2017

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Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.

27 September 2017

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Regulation of ribosomal S6 protein kinase-p90(rsk), glycogen synthase kinase 3, and beta-catenin in early Xenopus development

27 September 2017

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MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products

27 September 2017

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Metabotropic glutamate receptor-initiated translocation of protein kinase p90rsk to polyribosomes: a possible factor regulating synaptic protein synthesis

27 September 2017

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Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

27 September 2017

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

27 September 2017

1 reference

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Signal transduction via the MAP kinases: proceed at your own RSK.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1500846

Protein synthesis initiation factors from human HeLa cells and rabbit reticulocytes are similar: comparison of protein structure, activities, and immunochemical properties

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1500846

Growth-factor-dependent mitogenesis requires two distinct phases of signalling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1500846

Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1500846

Dissociation of double-stranded polynucleotide helical structures by eukaryotic initiation factors, as revealed by a novel assay

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1500846

Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors

30 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601166

Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601166

Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601166

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601166

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601166

Comparison of the specificities of p70 S6 kinase and MAPKAP kinase-1 identifies a relatively specific substrate for p70 S6 kinase: the N-terminal kinase domain of MAPKAP kinase-1 is essential for peptide phosphorylation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16763566

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16763566

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Eukaryotic protein synthesis initiation factor eIF-3: Determination of concentration and association with ribosomes in rabbit reticulocyte and HeLa cell lysates

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16763566

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.EMBOJ.7601166

1 reference

2332414

2332414

1 reference

1 reference

1 reference