Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system (Q28587541)

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28 December 2019

title

Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system (English)

2 references

31 January 2017

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Proprotein convertase subtilisin/kexin type 9

28 December 2019

main subject

1 reference

Proprotein convertase subtilisin/kexin type 2

GOA release 2020-03-11

1 reference

Proprotein convertase subtilisin/kexin type 9

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

0 references

2

1 reference

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28 December 2019

David C Baranowski

6

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28 December 2019

Nabil Seidah

9

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28 December 2019

author name string

Steve Poirier

1

2 references

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28 December 2019

Edwige Marcinkiewicz

3

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28 December 2019

Joanne Paquin

4

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28 December 2019

Benoit Cadieux

7

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28 December 2019

Babykumari P Chitramuthu

5

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28 December 2019

Hugh P J Bennett

8

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language of work or name

English

0 references

publication date

1 August 2006

2 references

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Journal of Neurochemistry

28 December 2019

published in

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volume

98

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page(s)

838-850

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issue

3

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

28 December 2019

cites work

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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

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Impaired fertility in mice deficient for the testicular germ-cell protease PC4

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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

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Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies

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Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

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Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

21 April 2017

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

21 April 2017

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Furin at the cutting edge: from protein traffic to embryogenesis and disease

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Effective targeted gene 'knockdown' in zebrafish

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Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia

21 April 2017

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Dual regulation of the LDL receptor--some clarity and new questions

21 January 2018

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PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues

21 January 2018

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Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

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NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

21 January 2018

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Defective prodynorphin processing in mice lacking prohormone convertase PC2.

21 January 2018

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 January 2018

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

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Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

21 January 2018

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Alternative proteolytic processing of mouse mammary tumor virus superantigens

21 January 2018

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Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

21 January 2018

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Heterologous processing of rat prosomatostatin to somatostatin-14 by PC2: requirement for secretory cell but not the secretion granule

21 January 2018

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The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1.

21 January 2018

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Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy

21 January 2018

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21 January 2018

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A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

21 January 2018

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RhoA/ROCK and Cdc42 regulate cell-cell contact and N-cadherin protein level during neurodetermination of P19 embryonal stem cells

21 January 2018

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The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P.

21 January 2018

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21 January 2018

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21 January 2018

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Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

21 January 2018

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Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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10.1111/J.1471-4159.2006.03928.X

21 January 2018

Identifiers

DOI

2 references

31 January 2017

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28 December 2019

2 references

31 January 2017