Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses (Q28551420)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26646986%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses (English)

1 reference

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2 March 2020

0 references

1 reference

5

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2 March 2020

Rebecca Broeckel

6

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2 March 2020

Ahmed M Al-Shammari

9

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2 March 2020

author name string

Tina M Sali

1

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2 March 2020

Kara M Pryke

2

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2 March 2020

Jinu Abraham

3

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2 March 2020

Andrew Liu

4

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2 March 2020

Julia A Staverosky

7

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2 March 2020

Jessica L Smith

8

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2 March 2020

Lisi Amsler

10

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2 March 2020

Kayla Sheridan

11

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2 March 2020

Aaron Nilsen

12

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2 March 2020

Daniel N Streblow

13

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2 March 2020

Victor R DeFilippis

14

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2 March 2020

language of work or name

English

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publication date

8 December 2015

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2 March 2020

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2 March 2020

volume

11

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2 March 2020

issue

12

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2 March 2020

page(s)

e1005324

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Creative Commons CC0 License

2 March 2020

copyright license

start time

8 December 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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cites work

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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The Src Family Kinase c-Yes Is Required for Maturation of West Nile Virus Particles

19 March 2017

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19 March 2017

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Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

19 March 2017

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19 March 2017

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19 March 2017

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

7 April 2017

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7 April 2017

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29 September 2017

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29 September 2017

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PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation

29 September 2017

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29 September 2017

Chikungunya on the move

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STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1.

29 September 2017

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STING agonists induce an innate antiviral immune response against hepatitis B virus

29 September 2017

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Cytosolic RNA:DNA hybrids activate the cGAS-STING axis

29 September 2017

1 reference

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Dendritic cell specific targeting of MyD88 signalling pathways in vivo

29 September 2017

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Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection

29 September 2017

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Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants

29 September 2017

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Improved vectors and genome-wide libraries for CRISPR screening

29 September 2017

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Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway

29 September 2017

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Pushing to a cure by harnessing innate immunity against hepatitis C virus

29 September 2017

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Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway

29 September 2017

1 reference

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Interferon-stimulated genes: a complex web of host defenses

29 September 2017

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29 September 2017

1 reference

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Zoonotic encephalitides caused by arboviruses: transmission and epidemiology of alphaviruses and flaviviruses

29 September 2017

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IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication.

29 September 2017

1 reference

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Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING.

29 September 2017

1 reference

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Chronic joint disease caused by persistent Chikungunya virus infection is controlled by the adaptive immune response

29 September 2017

1 reference

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Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Newly described pattern recognition receptors team up against intracellular pathogens

29 September 2017

1 reference

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cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Anticancer flavonoids are mouse-selective STING agonists.

29 September 2017

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Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid

29 September 2017

1 reference

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The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant

29 September 2017

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Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

29 September 2017

1 reference

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STING and the innate immune response to nucleic acids in the cytosol

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Defining critical roles for NF-κB p65 and type I interferon in innate immunity to rhinovirus.

29 September 2017

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5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential

29 September 2017

1 reference

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Regulators of innate immunity as novel targets for panviral therapeutics

29 September 2017

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The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation

29 September 2017

1 reference

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NF-κB and the link between inflammation and cancer

29 September 2017

1 reference

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Mechanism of substrate selection by a highly specific CRISPR endoribonuclease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Evaluation of innate immune signaling pathways in transformed cells

29 September 2017

1 reference

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Vascular disrupting agent DMXAA enhances the antitumor effects generated by therapeutic HPV DNA vaccines

29 September 2017

1 reference

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A mouse model of chikungunya virus-induced musculoskeletal inflammatory disease: evidence of arthritis, tenosynovitis, myositis, and persistence

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Pharmacologic activation of the innate immune system to prevent respiratory viral infections

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-beta-mediated antiviral activity in vitro and in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Activation of the interferon response by human cytomegalovirus occurs via cytoplasmic double-stranded DNA but not glycoprotein B.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Chikungunya virus arthritis in adult wild-type mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Persistent chronic inflammation and infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Cowpox virus inhibits the transporter associated with antigen processing to evade T cell recognition

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Synthetic and natural immunomodulators acting as interferon inducers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

The vascular disrupting agent, DMXAA, directly activates dendritic cells through a MyD88-independent mechanism and generates antitumor cytotoxic T lymphocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Stats: multifaceted regulators of transcription

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Identification of a novel pathway essential for the immediate-early, interferon-independent antiviral response to enveloped virions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Toll-like receptor signaling inhibits hepatitis B virus replication in vivo.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Analysis of genes induced by Sendai virus infection of mutant cell lines reveals essential roles of interferon regulatory factor 3, NF-kappaB, and interferon but not toll-like receptor 3

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Assembly of a functional beta interferon enhanceosome is dependent on ATF-2-c-jun heterodimer orientation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Protection Against Japanese Encephalitis Virus in Mice and Hamsters by Treatment with Carboxymethylacridanone, a Potent Interferon Inducer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Antiviral Activity of 10-Carboxymethyl-9-Acridanone

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Different STAT Transcription Complexes Drive Early and Delayed Responses to Type I IFNs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

The differential activity of interferon-α subtypes is consistent among distinct target genes and cell types

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Rhesus cytomegalovirus particles prevent activation of interferon regulatory factor 3.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Activation of LPS-inducible genes by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid in primary murine macrophages. Dissection of signaling pathways leading to gene induction and tyrosine phosphorylation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Comparative Therapeutic Efficacy of Recombinant Interferons-α, -β, and -γ Against Alphatogavirus, Bunyavirus, Flavivirus, and Herpesvirus Infections

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Activation of toll-like receptor signaling pathway for protection against influenza virus infection

3 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005324

Role of IFN-alpha/beta signaling in the prevention of genital herpes virus type 2 infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005324

MPYS/STING-mediated TNF-α, not type I IFN, is essential for the mucosal adjuvant activity of (3'-5')-cyclic-di-guanosine-monophosphate in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005324

Activation of tumor-associated macrophages by the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid induces an effective CD8+ T-cell-mediated antitumor immune response in murine models of lung cancer and mesothelioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005324

DMXAA: an antivascular agent with multiple host responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005324

Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005324

DNA-Mediated Cyclic GMP-AMP Synthase-Dependent and -Independent Regulation of Innate Immune Responses.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

An animal model for studying the pathogenesis of chikungunya virus infection

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Toll-like receptor-mediated control of HBV replication by nonparenchymal liver cells in mice

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

Interferon-inducible protein 10 induction and inhibition of angiogenesis in vivo by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4672893

STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-alpha

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26646986

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Differential responses to IFN-alpha subtypes in human T cells and dendritic cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26646986

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PPAT.1005324

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26646986%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26646986%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26646986%20AND%20SRC:MED&resulttype=core&format=json