Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response (Q28508156)

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17 November 2019

title

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response (English)

2 references

24 January 2017

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Activating transcription factor 3

17 November 2019

main subject

1 reference

DNA-damage inducible transcript 3

1 reference

Eukaryotic translation initiation factor 2 alpha kinase 3

1 reference

Eukaryotic translation initiation factor 2 alpha kinase 4

1 reference

Activating transcription factor 4

1 reference

author

Heather P Harding

6

1 reference

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17 November 2019

David Ron

8

1 reference

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17 November 2019

9

Douglas R Cavener

1 reference

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17 November 2019

author name string

Hao-Yuan Jiang

1

2 references

24 January 2017

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17 November 2019

Dan Lu

4

2 references

24 January 2017

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17 November 2019

Tsonwin Hai

5

2 references

24 January 2017

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17 November 2019

Xiaozhong Wang

7

2 references

24 January 2017

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17 November 2019

Sheree A Wek

2

1 reference

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17 November 2019

Barbara C McGrath

3

1 reference

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17 November 2019

Ronald C Wek

10

1 reference

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17 November 2019

language of work or name

English

0 references

publication date

1 February 2004

2 references

24 January 2017

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Molecular and Cellular Biology

17 November 2019

published in

2 references

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17 November 2019

volume

24

2 references

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17 November 2019

page(s)

1365-1377

1 reference

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17 November 2019

issue

3

2 references

24 January 2017

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Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite

17 November 2019

cites work

1 reference

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Activation of GCN2 in UV-irradiated cells inhibits translation

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19 March 2017

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The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

19 March 2017

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ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene

19 March 2017

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The roles of ATF3 in liver dysfunction and the regulation of phosphoenolpyruvate carboxykinase gene expression

19 March 2017

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Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

19 March 2017

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Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

19 March 2017

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IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

19 March 2017

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

19 March 2017

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

19 March 2017

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Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

19 March 2017

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Translational control is required for the unfolded protein response and in vivo glucose homeostasis

19 March 2017

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Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

19 March 2017

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Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

19 March 2017

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

19 March 2017

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PERK mediates cell-cycle exit during the mammalian unfolded protein response

19 March 2017

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Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

19 March 2017

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EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

19 March 2017

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Perk is essential for translational regulation and cell survival during the unfolded protein response

19 March 2017

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Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

19 March 2017

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A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha

19 March 2017

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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

19 March 2017

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PKR; a sentinel kinase for cellular stress

19 March 2017

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

19 March 2017

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Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

19 March 2017

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CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

19 March 2017

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The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response

19 March 2017

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19 March 2017

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Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

19 March 2017

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Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress

19 March 2017

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Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10

19 March 2017

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The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

19 March 2017

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Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control

19 March 2017

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CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

19 March 2017

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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

19 March 2017

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Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

7 April 2017

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Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast

7 April 2017

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Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

7 April 2017

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Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses

7 April 2017

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Stress-induced gene expression requires programmed recovery from translational repression

29 September 2017

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Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress

29 September 2017

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The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice

29 September 2017

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Transcriptional and translational control in the Mammalian unfolded protein response

29 September 2017

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The unfolded protein response in nutrient sensing and differentiation

29 September 2017

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RelB-p50 NF-kappa B complexes are selectively induced by cytomegalovirus immediate-early protein 1: differential regulation of Bcl-x(L) promoter activity by NF-kappa B family members

29 September 2017

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Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response

29 September 2017

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The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis

29 September 2017

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Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR.

29 September 2017

1 reference

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Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2).

29 September 2017

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Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

29 September 2017

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Amino acids control mammalian gene transcription: activating transcription factor 2 is essential for the amino acid responsiveness of the CHOP promoter

29 September 2017

1 reference

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Translational control of C/EBPalpha and C/EBPbeta isoform expression.

29 September 2017

1 reference

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ATF3 and stress responses.

29 September 2017

1 reference

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Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response

29 September 2017

1 reference

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Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer

29 September 2017

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Maintenance of nuclear factor-kappa B/Rel and c-myc expression during CD40 ligand rescue of WEHI 231 early B cells from receptor-mediated apoptosis through modulation of I kappa B proteins.

29 September 2017

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eIF-2 kinases: regulators of general and gene-specific translation initiation

29 September 2017

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Homologous recombination for gene replacement in mouse cell lines.

29 September 2017

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Generation of murine stromal cell lines supporting hematopoietic stem cell proliferation by use of recombinant retrovirus vectors encoding simian virus 40 large T antigen

29 September 2017

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Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents

29 September 2017

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Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress

29 September 2017

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The roles of ATF3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas

2 June 2018

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Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome

2 June 2018

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Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter

2 June 2018

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Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response

27 November 2018

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Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR.

27 November 2018

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Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frame

27 November 2018

1 reference

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Ultraviolet light inhibits translation through activation of the unfolded protein response kinase PERK in the lumen of the endoplasmic reticulum

27 November 2018

1 reference

12 December 2020

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response

1 reference

12 December 2020

Autopsy findings in the Wolcott-Rallison syndrome

1 reference

12 December 2020

Wolcott-Rallison syndrome: a case with endocrine and exocrine pancreatic deficiency and pancreatic hypotrophy

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12 December 2020

Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH(2)-terminal kinase and promoter response element.

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12 December 2020

Amino acid regulation of gene expression

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12 December 2020

10.1128/MCB.24.3.1365-1377.2004

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17 November 2019

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17 November 2019

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