Eukaryotic translation initiation factor 2 alpha kinase 4 (Q21984223)

Anticodon-binding domain superfamily

1 reference

eIF-2-alpha kinase Gcn2

1 reference

Ubiquitin-conjugating enzyme/RWD-like

1 reference

Histidyl tRNA synthetase-related domain, protein family

1 reference

RWD domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZ05&geneProductId=UniProtKB:Q9QZ05

protein kinase activity

1 reference

27 March 2018

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

eukaryotic initiation factor eIF2 binding

1 reference

14 February 2019

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

2 references

eukaryotic translation initiation factor 2alpha kinase activity

9 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZ05&geneProductId=UniProtKB:Q9QZ05

27 March 2018

The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZ05&geneProductId=UniProtKB:Q9QZ05

27 March 2018

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZ05&geneProductId=UniProtKB:Q9QZ05

27 March 2018

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZ05&geneProductId=UniProtKB:Q9QZ05

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZ05&geneProductId=UniProtKB:Q9QZ05

27 March 2018

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZ05&geneProductId=UniProtKB:Q9QZ05

27 March 2018

A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZ05&geneProductId=UniProtKB:Q9QZ05

27 March 2018

Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZ05&geneProductId=UniProtKB:Q9QZ05

27 March 2018

Activation of GCN2 in UV-irradiated cells inhibits translation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZ05&geneProductId=UniProtKB:Q9QZ05

eukaryotic translation initiation factor 2alpha kinase activity

10 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Activation of GCN2 in UV-irradiated cells inhibits translation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

1 reference

14 February 2019

IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

1 reference

27 March 2018

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZ05&geneProductId=UniProtKB:Q9QZ05

intracellular anatomical structure

ISS

1 reference

27 March 2018

GCN2 activation and eIF2alpha phosphorylation in the maturation of mouse oocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZ05&geneProductId=UniProtKB:Q9QZ05

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

negative regulation of translation

1 reference

14 February 2019

PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

positive regulation of translational initiation in response to starvation

IGI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

adaptive immune response

1 reference

14 February 2019

negative regulation of neuron differentiation

1 reference

14 February 2019

IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

positive regulation of long-term synaptic potentiation

1 reference

14 February 2019

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

positive regulation of adaptive immune response

1 reference

14 February 2019

Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

negative regulation of translational initiation in response to stress

1 reference

14 February 2019

Activation of GCN2 in UV-irradiated cells inhibits translation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

negative regulation of translational initiation

1 reference

14 February 2019

Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

immune system process

1 reference

14 February 2019

Activation of GCN2 in UV-irradiated cells inhibits translation

cellular response to UV

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

cellular response to starvation

1 reference

14 February 2019

IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

cellular response to amino acid starvation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

negative regulation of CREB transcription factor activity

1 reference

14 February 2019

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

regulation of feeding behavior

1 reference

14 February 2019

The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

1 reference

14 February 2019

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

response to endoplasmic reticulum stress

1 reference

14 February 2019

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

nervous system development

IGI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

1 reference

14 February 2019

Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

neuron projection extension

1 reference

14 February 2019

IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

endoplasmic reticulum unfolded protein response

1 reference

14 February 2019

PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores

protein phosphorylation

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Regulated translation initiation controls stress-induced gene expression in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

positive regulation of gene expression

1 reference

14 February 2019

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

cellular response to cold

2 references

1 reference

14 February 2019

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

defense response to virus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

cellular response to leucine starvation

1 reference

14 February 2019

IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

protein autophosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

negative regulation by host of viral genome replication

1 reference

14 February 2019

Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

regulation of translation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

regulation of translational initiation in response to stress

1 reference

14 February 2019

IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

regulation of translational initiation

1 reference

14 February 2019

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

positive regulation of defense response to virus by host

ISS

1 reference

14 February 2019

Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

T cell activation involved in immune response

1 reference

14 February 2019

Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

DNA damage checkpoint signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

regulation of translational initiation by eIF2 alpha phosphorylation

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Regulated translation initiation controls stress-induced gene expression in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

14 February 2019

Activation of GCN2 in UV-irradiated cells inhibits translation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZ05

Histidyl tRNA synthetase-related domain

has part(s)

1 reference

serine/threonine-protein kinase, active site

1 reference

RWD domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference