Presenilin 1 (Q21496912)

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mammalian protein found in Mus musculus
  • Protein S182
  • Psen1
  • presenilin-1
edit
Language Label Description Also known as
English
Presenilin 1
mammalian protein found in Mus musculus
  • Protein S182
  • Psen1
  • presenilin-1

Statements

molecular function
protein binding
determination method
IPI
13 references
retrieved
9 May 2019
stated in
Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IPI
retrieved
9 May 2019
stated in
Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IPI
retrieved
9 May 2019
stated in
Isolation and characterization of novel presenilin binding protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IPI
retrieved
9 May 2019
stated in
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IPI
retrieved
9 May 2019
stated in
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IPI
retrieved
9 May 2019
stated in
PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IPI
retrieved
9 May 2019
stated in
Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IPI
retrieved
9 May 2019
stated in
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IPI
retrieved
9 May 2019
stated in
Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IPI
retrieved
9 May 2019
stated in
Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IPI
retrieved
9 May 2019
stated in
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IPI
retrieved
9 May 2019
stated in
Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IPI
retrieved
9 May 2019
stated in
Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IPI
endopeptidase activity
determination method
IGI
IEA
IMP
ISO
12 references
retrieved
4 April 2017
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
ISO
retrieved
4 April 2017
stated in
Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IMP
retrieved
4 April 2017
stated in
Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IMP
retrieved
4 April 2017
stated in
The role of presenilin 1 during somite segmentation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IMP
retrieved
4 April 2017
stated in
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IMP
retrieved
4 April 2017
stated in
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IMP
retrieved
4 April 2017
stated in
Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IMP
retrieved
4 April 2017
stated in
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IMP
retrieved
4 April 2017
stated in
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IMP
retrieved
4 April 2017
stated in
Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IMP
retrieved
4 April 2017
stated in
Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IGI
retrieved
4 April 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IEA
endopeptidase activity
determination method
IBA
IEA
IGI
IMP
ISO
13 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
ISO
retrieved
9 May 2019
stated in
Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IMP
retrieved
9 May 2019
stated in
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IMP
retrieved
9 May 2019
stated in
Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IMP
retrieved
9 May 2019
stated in
Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IMP
retrieved
9 May 2019
stated in
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IMP
retrieved
9 May 2019
stated in
The role of presenilin 1 during somite segmentation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IMP
retrieved
9 May 2019
stated in
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IMP
retrieved
9 May 2019
stated in
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IMP
retrieved
9 May 2019
stated in
Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IMP
retrieved
9 May 2019
stated in
Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IGI
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IEA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IBA
cell component
membrane
determination method
IDA
IEA
8 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IEA
retrieved
9 May 2019
stated in
Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IDA
retrieved
9 May 2019
stated in
APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IDA
retrieved
9 May 2019
stated in
Spatial segregation of gamma-secretase and substrates in distinct membrane domains
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IDA
retrieved
9 May 2019
stated in
Isolation and characterization of novel presenilin binding protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IDA
retrieved
9 May 2019
stated in
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IDA
endoplasmic reticulum
determination method
IBA
IDA
IEA
ISO
ISS
7 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
ISS
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IEA
retrieved
9 May 2019
stated in
An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IDA
retrieved
9 May 2019
stated in
Isolation and characterization of novel presenilin binding protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IBA
biological process
endoplasmic reticulum calcium ion homeostasis
determination method
IGI
IEA
IMP
ISO
7 references
retrieved
4 April 2017
stated in
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
ISO
retrieved
4 April 2017
stated in
Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IMP
retrieved
4 April 2017
stated in
Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IMP
retrieved
4 April 2017
stated in
Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IMP
retrieved
4 April 2017
stated in
Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IMP
retrieved
4 April 2017
stated in
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IGI
retrieved
4 April 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49769
determination method
IEA
memory
determination method
IEA
IGI
IMP
ISO
TAS
7 references
retrieved
9 May 2019
stated in
Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
TAS
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
ISO
retrieved
9 May 2019
stated in
APP processing and synaptic plasticity in presenilin-1 conditional knockout mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IMP
retrieved
9 May 2019
stated in
Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IMP
retrieved
9 May 2019
stated in
Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IGI
retrieved
9 May 2019
stated in
Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IGI
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IEA
endoplasmic reticulum calcium ion homeostasis
determination method
IEA
IGI
IMP
ISO
ISS
8 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
ISS
retrieved
9 May 2019
stated in
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
ISO
retrieved
9 May 2019
stated in
Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IMP
retrieved
9 May 2019
stated in
Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IMP
retrieved
9 May 2019
stated in
Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IMP
retrieved
9 May 2019
stated in
Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IMP
retrieved
9 May 2019
stated in
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IGI
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49769
determination method
IEA

Identifiers

 
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