Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion (Q28478577)

1

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Karthigayan Shanmugasundaram

2

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Susan L Naylor

3

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Shu Lin

4

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Christine F O'Neill

6

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Dipen J Parekh

7

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I-Tien Yeh

8

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Lu-Zhe Sun

9

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Karen Block

Creative Commons Attribution 4.0 International

10

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language of work or name

English

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publication date

2011

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published in

PLOS One

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volume

6

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page(s)

e21037

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issue

6

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copyright license

start time

14 June 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

19 March 2017

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29 September 2017

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Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

29 September 2017

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HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation

29 September 2017

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RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Mutations in SDHC cause autosomal dominant paraganglioma, type 3.

21 January 2018

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Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis.

21 January 2018

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Conventional renal cancer in a patient with fumarate hydratase mutation

21 January 2018

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21 January 2018

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21695080

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

[Expression of hypoxia-inducible factor-1-alpha, hypoxia-inducible factor-2alpha and vascular endothelial growth factor in sporadic clear cell renal cell renal cell carcinoma and their significance in the pathogenesis thereof]

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21695080