Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism. (Q42208253)

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8 February 2020

title

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism (English)

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8 February 2020

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Dmitri B. Papkovsky

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Peter J. Ratcliffe

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Julie Adam

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Simon Olpin

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Chris Pugh

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Houman Ashrafian

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Patrick J Pollard

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author name string

Linda O'Flaherty

1

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Lisa C Heather

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Yuen-Li Chung

5

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Melroy X Miranda

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Joanne Croft

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Kieran Clarke

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John Griffiths

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publication date

21 July 2010

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8 February 2020

published in

Human Molecular Genetics

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volume

19

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8 February 2020

page(s)

3844-3851

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8 February 2020

issue

19

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Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response

8 February 2020

cites work

1 reference

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Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

26 October 2017

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

26 October 2017

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Expanding chemical biology of 2-oxoglutarate oxygenases

26 October 2017

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Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis.

26 October 2017

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26 October 2017

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Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway

26 October 2017

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Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

26 October 2017

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HIF and fumarate hydratase in renal cancer

26 October 2017

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Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

26 October 2017

1 reference

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Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

26 October 2017

1 reference

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Hypoxia signalling in cancer and approaches to enforce tumour regression

26 October 2017

1 reference

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Mitochondrial tumour suppressors: a genetic and biochemical update

26 October 2017

1 reference

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

26 October 2017

1 reference

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Hypoxia--a key regulatory factor in tumour growth

26 October 2017

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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

26 October 2017

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Mitochondrial and cytosolic isoforms of yeast fumarase are derivatives of a single translation product and have identical amino termini

26 October 2017

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Inherited susceptibility to uterine leiomyomas and renal cell cancer

26 October 2017

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Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

26 October 2017

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The single translation product of the FUM1 gene (fumarase) is processed in mitochondria before being distributed between the cytosol and mitochondria in Saccharomyces cerevisiae

26 October 2017

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26 October 2017

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17 August 2018

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Monoclonal antibody-based screening assay for factor inhibiting hypoxia-inducible factor inhibitors

17 August 2018

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17 August 2018

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17 August 2018

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Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20660115

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDQ305

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8 February 2020

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8 February 2020

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