Targeting leukocyte integrins in human diseases (Q28293910)

Journal of Leukocyte Biology

Europe PubMed Central

title

Targeting leukocyte integrins in human diseases (English)

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author name string

Karyn Yonekawa

series ordinal

1

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John M Harlan

series ordinal

2

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language of work or name

English

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publication date

February 2005

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published in

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volume

77

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issue

2

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page(s)

129-40

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cites work

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T-Cell Function and Migration — Two Sides of the Same Coin

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Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble

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Integrin avidity regulation: are changes in affinity and conformation underemphasized?

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New insights into the structural basis of integrin activation.

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Therapeutic antagonists and conformational regulation of integrin function

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Glycoprotein IIb/IIIa receptor inhibitors in percutaneous coronary intervention and acute coronary syndrome

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Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents

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Alpha 4 integrin antagonists

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Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases

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Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease

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Adhesion molecules as therapeutic targets for autoimmune diseases and transplant rejection

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Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin

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Integrins: bidirectional, allosteric signaling machines

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Integrin activation and structural rearrangement

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Genetic analysis of integrin function in man: LAD-1 and other syndromes.

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Integrin-dependent pathologies

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An Abnormal Platelet Glycoprotein Pattern in Three Cases of Glanzmann's Thrombasthenia

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Platelet membrane defects in Glanzmann's thrombasthenia. Evidence for decreased amounts of two major glycoproteins

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Hematologically important mutations: leukocyte adhesion deficiency

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Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands

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Inherited deficiency of the Mac-1, LFA-1, p150,95 glycoprotein family and its molecular basis

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Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins

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A novel syndrome of variant leukocyte adhesion deficiency involving defects in adhesion mediated by beta1 and beta2 integrins

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A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins

21 January 2018

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A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow.

21 January 2018

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LAD-III, a novel group of leukocyte integrin activation deficiencies.

21 January 2018

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Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia

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Homozygous alpha6 integrin mutation in junctional epidermolysis bullosa with congenital duodenal atresia.

21 January 2018

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Novel ITGB4 mutations in lethal and nonlethal variants of epidermolysis bullosa with pyloric atresia: missense versus nonsense

21 January 2018

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Mutations in the integrin alpha7 gene cause congenital myopathy

21 January 2018

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Integrin alpha 7 beta 1 in muscular dystrophy/myopathy of unknown etiology.

21 January 2018

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Selectins: lectins that initiate cell adhesion under flow

21 January 2018

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The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses

21 January 2018

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The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment

21 January 2018

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Locomotion of monocytes on endothelium is a critical step during extravasation.

21 January 2018

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PECAM-1 is required for transendothelial migration of leukocytes

21 January 2018

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JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes

21 January 2018

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JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration

21 January 2018

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Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP

21 January 2018

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alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow

21 January 2018

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The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.

21 January 2018

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Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction

21 January 2018

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CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte-endothelial cell primary adhesion pathway

21 January 2018

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VAP-1: an adhesin and an enzyme

21 January 2018

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Selectins and neutrophil traffic: margination and Streptococcus pneumoniae-induced emigration in murine lungs

21 January 2018

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A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature

21 January 2018

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Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor

21 January 2018

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The complexities of leukocyte recruitment

21 January 2018

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Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway

21 January 2018

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Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)

21 January 2018

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The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.0804460

JAM2 interacts with alpha4beta1. Facilitation by JAM3

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Cell migration: integrating signals from front to back

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.0804460

Adhesion mechanisms regulating the migration of monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

VLA-4 antagonists: potent inhibitors of lymphocyte migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Integrin-dependent neutrophil migration in extravascular tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Integrin-dependent regulation of gene expression in leukocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Alpha4 integrins and the immune response

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.0804460

Get a ligand, get a life: integrins, signaling and cell survival

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.0804460

Diverse roles of integrins in human T lymphocyte biology

21 January 2018

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Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.0804460

Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.0804460

Regulation of inflammation by collagen-binding integrins alpha1beta1 and alpha2beta1 in models of hypersensitivity and arthritis

21 January 2018

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Collagen-binding integrin alpha1beta1 regulates intestinal inflammation in experimental colitis

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.0804460

The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection.

21 January 2018

1 reference

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A monoclonal antibody to alpha1beta1 blocks antigen-induced airway responses in sheep.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.0804460

Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.0804460

Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Synergistic mobilization of hemopoietic progenitor cells using concurrent beta1 and beta2 integrin blockade or beta2-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.0804460

Use of anti-ICAM-1 therapy in ischemic stroke: results of the Enlimomab Acute Stroke Trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Clinical effects of inhibiting leukocyte adhesion with monoclonal antibody to intercellular adhesion molecule-1 (enlimomab) in the treatment of partial-thickness burn injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Pulmonary eosinophilia in a murine model of allergic inflammation is attenuated by small molecule alpha4beta1 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

21 January 2018

The leukocyte integrins

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Membranes as messengers in T cell adhesion signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines: critical role of LFA-1 affinity triggering in lymphocyte in vivo homing

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Vav GEFs are required for beta2 integrin-dependent functions of neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Natalizumab for active Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Absence of efficacy of subcutaneous antisense ICAM-1 treatment of chronic active Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

A controlled trial of natalizumab for relapsing multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Efalizumab for patients with moderate to severe plaque psoriasis: a randomized controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): an adaptive dose-response study of UK-279,276 in acute ischemic stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

A randomized multicenter trial comparing leukocyte function-associated antigen-1 monoclonal antibody with rabbit antithymocyte globulin as induction treatment in first kidney transplantations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Clinical trials of transplant tolerance: slow but steady progress

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Recombinant humanized monoclonal antibody against CD18 (rhuMAb CD18) in traumatic hemorrhagic shock: results of a phase II clinical trial. Traumatic Shock Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Selective Inhibition of Endothelial and Monocyte Redox-Sensitive Genes by AGI-1067: A Novel Antioxidant and Anti-Inflammatory Agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Pharmacological modulation of endothelial cell-associated adhesion molecule expression: implications for future treatment of dermatological diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Anti-P-selectin monoclonal antibody attenuates reperfusion injury to the rabbit ear.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Inhibition of leukocyte adherence by anti-CD18 monoclonal antibody attenuates reperfusion injury in the rabbit ear.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Reduction of myocardial infarct size by neutrophil depletion: effect of duration of occlusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

The caspase inhibitor z-VAD is more effective than CD18 adhesion blockade in reducing muscle ischemia-reperfusion injury: implication for clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

A major role for VCAM-1, but not ICAM-1, in early atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Effects of AGI-1067 and probucol after percutaneous coronary interventions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

The role of the leukocyte adhesion molecules VLA-4, LFA-1, and Mac-1 in allergic airway responses in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Inflammatory Bowel Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Adhesion molecules in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

T-cell modulation for the treatment of chronic plaque psoriasis with efalizumab (Raptiva): mechanisms of action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Therapeutic inhibition of leukocyte recruitment in inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Cell adhesion molecules in clinical renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Blockade of the integrin alphaLbeta2 but not of integrins alpha4 and/or beta7 significantly prolongs intestinal allograft survival in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460

Pathophysiology of acute graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0804460