Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling (Q28291363)

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Insulin signal transduction and the IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Insulin receptor substrate 1 and 2 (IRS1 and IRS2): what a tangled web we weave.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Not all Shc's roads lead to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Mitogen-activated protein kinases: versatile transducers for cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Insulin-like growth factor-I-mediated neurite outgrowth in vitro requires mitogen-activated protein kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Enhancement or inhibition of insulin signaling by insulin receptor substrate 1 is cell context dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Insulin-like Growth Factors as Regulators of Cell Motility Signaling Mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Insulin-like growth factors regulate neuronal differentiation and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Bidirectional regulation of p38 kinase and c-Jun N-terminal protein kinase by insulin-like growth factor-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

The role of the Shc phosphotyrosine interaction/phosphotyrosine binding domain and tyrosine phosphorylation sites in polyoma middle T antigen-mediated cell transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Functional importance of Shc tyrosine 317 on insulin signaling in Rat1 fibroblasts expressing insulin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Membrane ruffling and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Insulin-like growth factor-1-mediated association of p85 phosphatidylinositol 3-kinase with pp 185: requirement of SH2 domains for in vivo interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

SH3 domains direct cellular localization of signaling molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.34543