DNA damage and the balance between survival and death in cancer biology (Q28271163)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26678314%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

DNA damage and the balance between survival and death in cancer biology (English)

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2 March 2020

0 references

1

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2 March 2020

Adam D Thomas

series ordinal

2

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2 March 2020

author name string

Bernd Kaina

series ordinal

3

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2 March 2020

language of work or name

English

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publication date

18 December 2015

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2 March 2020

published in

Nature Reviews Cancer

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2 March 2020

volume

16

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26678314%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

page(s)

20-33

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2 March 2020

issue

1

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DNA damage induced by endogenous aldehydes: current state of knowledge

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Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2.

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Caspase-2 cleaves DNA fragmentation factor (DFF45)/inhibitor of caspase-activated DNase (ICAD).

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Death through a tragedy: mitotic catastrophe

31 March 2020

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Dynamics of the p53-Mdm2 feedback loop in individual cells

31 March 2020

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Cell fate decision mediated by p53 pulses

31 March 2020

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A two-step mechanism for cell fate decision by coordination of nuclear and mitochondrial p53 activities.

31 March 2020

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31 March 2020

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31 March 2020

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p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

31 March 2020

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DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage

31 March 2020

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XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313

31 March 2020

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Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.

31 March 2020

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31 March 2020

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p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

31 March 2020

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31 March 2020

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31 March 2020

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A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

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The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers.

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31 March 2020

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c-Fos is involved in the cellular defence against the genotoxic effect of UV radiation

31 March 2020

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c-Fos is required for excision repair of UV-light induced DNA lesions by triggering the re-synthesis of XPF

31 March 2020

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DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1.

31 March 2020

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Long-term activation of SAPK/JNK, p38 kinase and fas-L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistance.

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Mitogen-activated protein kinase phosphatases inactivate stress-activated protein kinase pathways in vivo

31 March 2020

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A role for UV-light-induced c-Fos: Stimulation of nucleotide excision repair and protection against sustained JNK activation and apoptosis

31 March 2020

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Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by IFN-β and valproic acid.

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Human Sir2 and the 'silencing' of p53 activity

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

31 March 2020

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Role of p16(INK4A) in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells

31 March 2020

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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

31 March 2020

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Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

31 March 2020

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TRF2 Protects Human Telomeres from End-to-End Fusions

31 March 2020

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TRF2 inhibition promotes anchorage-independent growth of telomerase-positive human fibroblasts.

31 March 2020

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Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53

31 March 2020

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Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage

31 March 2020

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Regulation of PTEN transcription by p53

31 March 2020

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31 March 2020

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Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy

31 March 2020

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Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells

31 March 2020

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DRAM-1 encodes multiple isoforms that regulate autophagy

31 March 2020

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Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

31 March 2020

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Mechanism of adriamycin cardiotoxicity: evidence for oxidative stress

31 March 2020

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PARP-1 is involved in autophagy induced by DNA damage.

31 March 2020

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ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy

31 March 2020

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Autophagic-lysosomal dysregulation downstream of cathepsin B inactivation in human skin fibroblasts exposed to UVA.

31 March 2020

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IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner

31 March 2020

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ATM engages the TSC2/mTORC1 signaling node to regulate autophagy.

31 March 2020

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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

31 March 2020

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Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage

31 March 2020

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

31 March 2020

1 reference

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Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation

31 March 2020

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Another way to die: autophagic programmed cell death

31 March 2020

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Functional interaction between FOXO3a and ATM regulates DNA damage response

31 March 2020

1 reference

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Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein

31 March 2020

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Cellular autophagic capacity is highly increased in azaserine-induced premalignant atypical acinar nodule cells

31 March 2020

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Life or death? Autophagy in anticancer therapies with statins and histone deacetylase inhibitors.

31 March 2020

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Autophagy as a cell death and tumor suppressor mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.

31 March 2020

1 reference

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Survivin and IAP proteins in cell-death mechanisms

31 March 2020

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Monitoring survivin expression in cancer: implications for prognosis and therapy

31 March 2020

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Survivin, a target to modulate the radiosensitivity of Ewing's sarcoma

31 March 2020

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Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress

31 March 2020

1 reference

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Nuclear survivin expression: a prognostic factor for the response to taxane-platinum chemotherapy in patients with advanced non-small cell lung cancer.

31 March 2020

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Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

31 March 2020

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p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK.

31 March 2020

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Functional switching of ATM: sensor of DNA damage in proliferating cells and mediator of Akt survival signal in post-mitotic human neuron-like cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Regulation of cell death protease caspase-9 by phosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Targeting the weak point of cancer by induction of necroptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Bioenergetic aspects of apoptosis, necrosis and mitoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Caspase 8 inhibits programmed necrosis by processing CYLD

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Mitochondrial and nuclear cross talk in cell death: parthanatos

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Poly(ADP-ribose). The most elaborate metabolite of NAD+.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

NAD+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Apoptosis-inducing factor deficiency decreases the proliferation rate and protects the subventricular zone against ionizing radiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Energy adaptive response during parthanatos is enhanced by PD98059 and involves mitochondrial function but not autophagy induction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Reversibility of apoptosis in cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Human embryonic stem cells have enhanced repair of multiple forms of DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Terminally differentiated muscle cells are defective in base excision DNA repair and hypersensitive to oxygen injury.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

High expression of DNA repair pathways is associated with metastasis in melanoma patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Translesion polymerase η is upregulated by cancer therapeutics and confers anticancer drug resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Retracted: Ubiquitin/SUMO Modification Regulates VHL Protein Stability and Nucleocytoplasmic Localization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Signalling loops and linear pathways: NF-kappaB activation in response to genotoxic stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Identification of NF-kappa B-regulated genes induced by TNFalpha utilizing expression profiling and RNA interference

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

Akt promotes post-irradiation survival of human tumor cells through initiation, progression, and termination of DNA-PKcs-dependent DNA double-strand break repair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.2

A general role for c-Fos in cellular protection against DNA-damaging carcinogens and cytostatic drugs

31 March 2020

1 reference

12 December 2020

Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent

1 reference

12 December 2020

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs

1 reference

12 December 2020

Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation

1 reference

12 December 2020

Induction of autophagic cell death in malignant glioma cells by arsenic trioxide.

1 reference

12 December 2020

O(6)-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: enzyme activity, promoter methylation and immunohistochemistry

1 reference

12 December 2020

Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition.

1 reference

12 December 2020

Reactive oxygen species regulation of autophagy in cancer: implications for cancer treatment

1 reference

12 December 2020

Cell death signaling and anticancer therapy

1 reference

12 December 2020

DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC.2015.2

2 references

Consolidated OpenCitations Corpus – April 2017

657085

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26678314%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

2 March 2020

1052347391

0 references

Fatcat ID

release_hkdtzcck4rdg5ee5cfasmmo47e

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hkdtzcck4rdg5ee5cfasmmo47e

24 November 2022

mapped directly with Wikidata item

657085

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

657085

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26678314%20AND%20SRC:MED&resulttype=core&format=json