The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death (Q28260835)

2

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Toru Hirota

3

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Shin-Ichi Iida

4

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Toshihiro Hara

5

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Shinobu Honda

6

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Naoko Kunitoku

7

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Takashi Sasayama

8

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Yoshimi Arima

9

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Tomotoshi Marumoto

10

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Kageharu Koja

11

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Shin Yonehara

12

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Hideyuki Saya

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

13

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language of work or name

English

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publication date

11 August 2005

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published in

Oncogene

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volume

24

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issue

34

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page(s)

5287-98

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cites work

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Size control in animal development

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia

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Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

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Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

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Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor

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Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition

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The conformational plasticity of protein kinases

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Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function

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Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

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Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

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Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein

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The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

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WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis

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A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

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Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2

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A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

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Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

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Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells

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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

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Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways

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Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

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Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15

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HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

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Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

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LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

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Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

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The Bcl2 family: regulators of the cellular life-or-death switch

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Plat-E: an efficient and stable system for transient packaging of retroviruses

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IAP proteins: blocking the road to death's door

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Competition and compensation: coupled to death in development and cancer

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Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death

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The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

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Caspase-dependent Cdk activity is a requisite effector of apoptotic death events

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Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma

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The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

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Four deaths and a funeral: from caspases to alternative mechanisms.

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Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi

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The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.

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Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

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The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria

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Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

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hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

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Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms

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Apoptosis and the cell cycle

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1208682

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

691315

1035628340

0 references

691315

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference