Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer (Q28298475)

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Manel Esteller

object named as

M Esteller

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author name string

O Aguilera

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M F Fraga

2

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M F Paz

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M Herranz

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J M García

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A Muñoz

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J M González-Sancho

EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma.

10

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language of work or name

English

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publication date

6 July 2006

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published in

Oncogene

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volume

25

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page(s)

4116-21

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issue

29

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cites work

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7 January 2021

An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells

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Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

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The impact of chromatin in human cancer: linking DNA methylation to gene silencing

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Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer.

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FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development

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A genetic model for colorectal tumorigenesis

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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

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A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors

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Cancer survival and incidence from the Surveillance, Epidemiology, and End Results (SEER) program

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The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer

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7 January 2021

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

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7 January 2021

Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations.

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7 January 2021

Secreted antagonists of the Wnt signalling pathway

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Lessons from hereditary colorectal cancer

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Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1.

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7 January 2021

Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma

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7 January 2021

Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

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Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer

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A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation

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DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway

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7 January 2021

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

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7 January 2021

Signaling pathways in intestinal development and cancer

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7 January 2021

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

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7 January 2021

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

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7 January 2021

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209439

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1584309

1002127420

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1584309

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference