Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy (Q27853119)

13 November 2016

title

Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy (English)

1 reference

13 November 2016

4

Peggy L Porter

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author name string

Hui Zhao

1

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Claire M Faltermeier

2

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Lori Mendelsohn

3

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Bruce E Clurman

5

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James M Roberts

A new description of cellular quiescence

6

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language of work or name

English

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publication date

30 December 2014

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published in

Oncotarget

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volume

5

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issue

24

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page(s)

12704-14

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cites work

1 reference

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Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions

20 March 2017

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Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

20 March 2017

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Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade

20 March 2017

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CDK inhibitors: positive and negative regulators of G1-phase progression

20 March 2017

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

20 March 2017

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

20 March 2017

1 reference

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Significance of skp2 expression in primary breast cancer

20 March 2017

1 reference

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p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion

20 March 2017

1 reference

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

20 March 2017

1 reference

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Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer

7 April 2017

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Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma.

29 September 2017

1 reference

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Control of the reversibility of cellular quiescence by the transcriptional repressor HES1.

29 September 2017

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The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

29 September 2017

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A mechanism misregulating p27 in tumors discovered in a functional genomic screen

29 September 2017

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Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma

29 September 2017

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Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype

29 September 2017

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Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity

29 September 2017

1 reference

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A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression

29 September 2017

1 reference

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A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.

29 September 2017

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p27Kip1 modulates cell migration through the regulation of RhoA activation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350358

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350358

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350358

ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350358

Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27(Kip1)

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350358

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350358

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350358

The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350358

Cytoplasmic p27Kip1 counteracts the pro-apoptotic function of the open conformation of PTEN by retention and destabilization of PTEN outside of the nucleus.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350358

Prognostic significance of cytoplasmic p27 expression in human melanoma.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350358

Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350358

Cytoplasmic p27 expression is an independent prognostic factor in ovarian cancer.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350358

Subcellular localization of p27kip1 expression predicts poor prognosis in human ovarian cancer.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350358

Association between the nuclear to cytoplasmic ratio of p27 and the efficacy of adjuvant polychemotherapy in early breast cancer

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25587029

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/25587029

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Clinical significance of HER-2/neu oncogene amplification in primary breast cancer. The South Australian Breast Cancer Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/25587029

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.2871

0 references

1 reference

13 November 2016

1 reference