p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. (Q27851827)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22698404%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer (English)

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5 February 2020

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1

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5 February 2020

author name string

Vinod Pant

2

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5 February 2020

Qin Li

3

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5 February 2020

Leslie L Chang

4

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5 February 2020

Alfonso Quintás-Cardama

5

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5 February 2020

Daniel Garza

6

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5 February 2020

Omid Tavana

7

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5 February 2020

Peirong Yang

8

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5 February 2020

Taghi Manshouri

9

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5 February 2020

Yi Li

10

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5 February 2020

Adel K El-Naggar

11

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Guillermina Lozano

12

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5 February 2020

publication date

1 June 2012

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5 February 2020

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5 February 2020

volume

21

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5 February 2020

page(s)

793-806

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5 February 2020

issue

6

1 reference

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Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen

5 February 2020

cites work

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Chemokine signaling via the CXCR2 receptor reinforces senescence

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Transcriptional control of human p53-regulated genes

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p53 is required for radiation-induced apoptosis in mouse thymocytes

7 April 2017

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

7 April 2017

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7 April 2017

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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

7 April 2017

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Radiation-induced cell cycle arrest compromised by p21 deficiency

7 April 2017

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Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

7 April 2017

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TP53 status for prediction of sensitivity to taxane versus non-taxane neoadjuvant chemotherapy in breast cancer (EORTC 10994/BIG 1-00): a randomised phase 3 trial

29 September 2017

1 reference

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Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.

29 September 2017

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Cyclophosphamide dose intensification may circumvent anthracycline resistance of p53 mutant breast cancers

29 September 2017

1 reference

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p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis

29 September 2017

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Cytokine expression and signaling in drug-induced cellular senescence.

29 September 2017

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TP53 status and response to chemotherapy in breast cancer

29 September 2017

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Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.

29 September 2017

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29 September 2017

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Prognostic and predictive effects of immunohistochemical factors in high-risk primary breast cancer patients

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Disruption of p53 in human cancer cells alters the responses to therapeutic agents

29 September 2017

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29 September 2017

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2 June 2018

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2 June 2018

1 reference

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p53 protein overexpression and chemosensitivity in breast cancer. Institut Gustave-Roussy Breast Cancer Group.

2 June 2018

1 reference

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Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

2 June 2018

1 reference

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p53 dependent cell-cycle arrest triggered by chemotherapy in xenografted breast tumors.

2 June 2018

1 reference

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Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression

27 November 2018

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The role of apoptosis in cancer development and treatment response

27 November 2018

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

27 November 2018

1 reference

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Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.

27 November 2018

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A mutant TP53 gene status is associated with a poor prognosis and anthracycline-resistance in breast cancer patients

27 November 2018

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Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy

27 November 2018

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DNA damage is able to induce senescence in tumor cells in vitro and in vivo.

27 November 2018

1 reference

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Thymocyte apoptosis induced by p53-dependent and independent pathways.

27 November 2018

1 reference

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p53 protein overexpression and chemosensitivity in breast cancer.

27 November 2018

1 reference

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p53 mutations occur in aggressive breast cancer

27 November 2018

1 reference

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Effect of fixation and epitope retrieval on BrdU indices in mammary carcinomas

27 November 2018

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12 December 2020

Genetic determinants of response to chemotherapy in transgenic mouse mammary and salivary tumors

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12 December 2020

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

1 reference

12 December 2020

p53 status and the efficacy of cancer therapy in vivo

1 reference

12 December 2020

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability

1 reference

12 December 2020

A subset of p53-deficient embryos exhibit exencephaly

1 reference

12 December 2020

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

1 reference

12 December 2020

Cell-cycle arrest versus cell death in cancer therapy

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12 December 2020

Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

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10.1016/J.CCR.2012.04.027

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22698404%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22698404%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22698404%20AND%20SRC:MED&resulttype=core&format=json