Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism (Q27727293)

26 September 2017

Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism (English)

1 reference

26 September 2017

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2

Roderick MacKinnon

Roderick

MacKinnon

1 reference

20 October 2023

Jonathan R Whicher

1

Jonathan R

Whicher

2 references

26 September 2017

20 October 2023

language of work or name

English

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publication date

1 August 2016

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26 September 2017

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26 September 2017

353

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26 September 2017

664-669

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26 September 2017

6300

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Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

26 September 2017

1 reference

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Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

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1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAF8070

The crystal structure of a voltage-gated sodium channel

20 April 2017

1 reference

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Structure of the voltage-gated calcium channel Cav1.1 complex

20 April 2017

1 reference

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Mechanistic Insight into Human ether-a-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG Domain

20 April 2017

1 reference

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Structural basis for modulation and agonist specificity of HCN pacemaker channels

20 April 2017

1 reference

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Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods

20 April 2017

1 reference

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Structure of the carboxy-terminal region of a KCNH channel

20 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAF8070

Structural, biochemical, and functional characterization of the cyclic nucleotide binding homology domain from the mouse EAG1 potassium channel

20 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAF8070

Inhibition of human ether à go-go potassium channels by Ca(2+)/calmodulin

20 April 2017

1 reference

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Inhibition of human ether à go-go potassium channels by Ca2+/calmodulin binding to the cytosolic N- and C-termini

20 April 2017

1 reference

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Oncogenic potential of EAG K(+) channels

20 April 2017

1 reference

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Ether à go-go potassium channel expression in soft tissue sarcoma patients

20 April 2017

1 reference

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Astemizole synergizes calcitriol antiproliferative activity by inhibiting CYP24A1 and upregulating VDR: a novel approach for breast cancer therapy

20 April 2017

1 reference

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Carboxy-terminal domain mediates assembly of the voltage-gated rat ether-à-go-go potassium channel

20 April 2017

1 reference

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Molecular identification and characterisation of the human eag2 potassium channel

20 April 2017

1 reference

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X-ray structure of a voltage-dependent K+ channel

20 April 2017

1 reference

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14-3-3θ is a binding partner of rat Eag1 potassium channels

20 April 2017

1 reference

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20 April 2017

1 reference

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1 reference

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1 reference

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1 reference

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Calmodulin structure refined at 1.7 A resolution

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1 reference

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1 reference

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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1 reference

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1 reference

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1 reference

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Collaboration gets the most out of software

20 April 2017

1 reference

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Automated electron microscope tomography using robust prediction of specimen movements

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1 reference

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PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations

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1 reference

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Bsoft: image processing and molecular modeling for electron microscopy

20 April 2017

1 reference

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Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy

20 April 2017

2 references

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20 April 2017

https://pubmed.ncbi.nlm.nih.gov/27516594

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

1 reference

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Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477842

The structural mechanism of KCNH-channel regulation by the eag domain.

29 September 2017

1 reference

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Likelihood-based classification of cryo-EM images using FREALIGN

29 September 2017

1 reference

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A Bayesian view on cryo-EM structure determination.

29 September 2017

1 reference

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The potassium channel Ether à go-go is a novel prognostic factor with functional relevance in acute myeloid leukemia

29 September 2017

1 reference

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Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors

29 September 2017

1 reference

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Overexpression of Eag1 potassium channels in clinical tumours.

29 September 2017

1 reference

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Gating charges in the activation and inactivation processes of the HERG channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477842

Ion conduction pore is conserved among potassium channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477842

Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain

29 September 2017

1 reference

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Regulation of deactivation by an amino terminal domain in human ether-à-go-go-related gene potassium channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477842

Amino terminal-dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment

29 September 2017

1 reference

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HOLE: a program for the analysis of the pore dimensions of ion channel structural models

29 September 2017

1 reference

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Functional expression of a rat homologue of the voltage gated either á go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart

29 September 2017

1 reference

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Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions

29 September 2017

1 reference

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KV 10.1 opposes activity-dependent increase in Ca2+ influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse.

2 June 2018

1 reference

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Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477842

Conformation-independent structural comparison of macromolecules with ProSMART

2 June 2018

1 reference

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Activation gating of hERG potassium channels: S6 glycines are not required as gating hinges.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477842

2 June 2018

1 reference

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Contribution of the S4 segment to gating charge in the Shaker K+ channel.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477842

2 June 2018

1 reference

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Backbone dynamics of calmodulin studied by 15N relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible.

2 June 2018

1 reference

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Voltage sensor of Kv1.2: structural basis of electromechanical coupling

2 June 2018

1 reference

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Molecular regions responsible for differences in activation between heag channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF8070

An ether -à-go-go K+ current, Ih-eag, contributes to the hyperpolarization of human fusion-competent myoblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF8070

Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF8070

CTFFIND4: Fast and accurate defocus estimation from electron micrographs.

21 January 2018

1 reference

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Monoclonal Antibody Blockade of the Human Eag1 Potassium Channel Function Exerts Antitumor Activity

21 January 2018

1 reference

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Blocker protection in the pore of a voltage-gated K+ channel and its structural implications

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27516594

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.AAF8070

1 reference

OpenCitations bibliographic resource ID

26 September 2017

0 references

3028351

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

26 September 2017

1 reference

PMCID

5477842