Mechanistic Insight into Human ether-a-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG Domain (Q27666202)

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Language	Label	Description	Also known as
English	Mechanistic Insight into Human ether-a-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG Domain	scientific article

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scholarly article

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Mechanistic Insight into Human ether-a-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG Domain (English)

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solution structure

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based on heuristic

inferred from title

author name string

Frederick W Muskett

1

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Samrat Thouta

2

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Steven J Thomson

3

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Alexander Bowen

4

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Phillip J Stansfeld

5

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John S Mitcheson

6

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language of work or name

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publication date

25 February 2011

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Journal of Biological Chemistry

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286

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8

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6184-91

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A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels

1 reference

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20 March 2017

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel

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20 March 2017

Structure of the redox sensor domain of Azotobacter vinelandii NifL at atomic resolution: signaling, dimerization, and mechanism

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

Structural basis for modulation and agonist specificity of HCN pacemaker channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

The inward rectification mechanism of the HERG cardiac potassium channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

A family of potassium channel genes related to eag in Drosophila and mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

HERG, a human inward rectifier in the voltage-gated potassium channel family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

GROMACS: fast, flexible, and free

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

The Amber biomolecular simulation programs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

Torsion angle dynamics for NMR structure calculation with the new program DYANA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

MOLMOL: a program for display and analysis of macromolecular structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

A structural basis for drug-induced long QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

20 March 2017

Mammalian Per-Arnt-Sim proteins in environmental adaptation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

hERG gating microdomains defined by S6 mutagenesis and molecular modeling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

hERG potassium channels and cardiac arrhythmia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

CNG and HCN channels: two peas, one pod.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

Gating charges in the activation and inactivation processes of the HERG channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

Molecular and cellular mechanisms of cardiac arrhythmias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

Dynamic control of deactivation gating by a soluble amino-terminal domain in HERG K(+) channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

Regulation of deactivation by an amino terminal domain in human ether-à-go-go-related gene potassium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

Time course and voltage dependence of expressed HERG current compared with native "rapid" delayed rectifier K current during the cardiac ventricular action potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

Fast inactivation causes rectification of the IKr channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

29 September 2017

Molecular determinants of dofetilide block of HERG K+ channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

2 June 2018

A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

2 June 2018

Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

2 June 2018

Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

2 June 2018

Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199364

21 January 2018

Alteration of HERG current profile during the cardiac ventricular action potential, following a pore mutation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199364

21 January 2018

Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199364

21 January 2018

Role of intracellular domains in the function of the herg potassium channel

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199364

21 January 2018

ZDOCK: an initial-stage protein-docking algorithm.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199364

21 January 2018

ZRANK: reranking protein docking predictions with an optimized energy function.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199364

21 January 2018

Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199364

21 January 2018

Structural determinants of HERG channel block by clofilium and ibutilide.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199364

21 January 2018

Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199364

21 January 2018

Resonance assignment and secondary structure prediction of the N-terminal domain of hERG (Kv11.1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

27 November 2018

Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057830

27 November 2018

Ionic mechanisms for prolongation of refractoriness and their proarrhythmic and antiarrhythmic correlates

1 reference

https://pubmed.ncbi.nlm.nih.gov/21135103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural diversity in p160/CREB-binding protein coactivator complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21135103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of premature stimulation on HERG K(+) channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/21135103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.199364

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

release_o6nw3oxv3fhnbix3wgp2p5b4ze

0 references

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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