A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMP (Q27684011)

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19 March 2020

title

A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP (English)

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19 March 2020

0 references

3

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19 March 2020

Rajeevan Selvaratnam

4

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19 March 2020

author name string

Madoka Akimoto

1

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19 March 2020

Zaiyong Zhang

2

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19 March 2020

Bryan VanSchouwen

5

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19 March 2020

Melanie Gloyd

6

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19 March 2020

Eric A Accili

7

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19 March 2020

Oliver F Lange

8

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19 March 2020

Giuseppe Melacini

9

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19 March 2020

language of work or name

English

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publication date

30 May 2014

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Journal of Biological Chemistry

19 March 2020

published in

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19 March 2020

volume

289

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19 March 2020

issue

32

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19 March 2020

page(s)

22205-22220

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PKA RIα Homodimer Structure Reveals an Intermolecular Interface with Implications for Cooperative cAMP Binding and Carney Complex Disease

19 March 2020

cites work

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Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels

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Structure of the BamC Two-Domain Protein Obtained by Rosetta with a Limited NMR Data Set

20 March 2017

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Co-Crystal Structures of PKG Iβ (92–227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding

20 March 2017

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Structural insights into conformational changes of a cyclic nucleotide-binding domain in solution from Mesorhizobium loti K1 channel

20 March 2017

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Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design

20 March 2017

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Dynamics connect substrate recognition to catalysis in protein kinase A

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Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

20 March 2017

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20 March 2017

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20 March 2017

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PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation

20 March 2017

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Structure and Rearrangements in the Carboxy-Terminal Region of SpIH Channels

20 March 2017

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Structural basis for modulation and agonist specificity of HCN pacemaker channels

20 March 2017

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20 March 2017

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Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels

20 March 2017

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20 March 2017

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The auto-inhibitory role of the EPAC hinge helix as mapped by NMR

20 March 2017

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HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels

20 March 2017

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The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides

20 March 2017

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20 March 2017

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20 March 2017

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Utilization of site-directed spin labeling and high-resolution heteronuclear nuclear magnetic resonance for global fold determination of large proteins with limited nuclear overhauser effect data

7 April 2017

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Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR.

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Asymmetric divergence in structure and function of HCN channel duplicates in Ciona intestinalis

29 September 2017

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Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP

29 September 2017

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Accurate protein structure modeling using sparse NMR data and homologous structure information

29 September 2017

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The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants.

29 September 2017

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cAMP-dependent allostery and dynamics in Epac: an NMR view.

29 September 2017

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Energetics of cyclic AMP binding to HCN channel C terminus reveal negative cooperativity

29 September 2017

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Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry

29 September 2017

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Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC)

29 September 2017

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Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy

29 September 2017

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Determination of the structures of symmetric protein oligomers from NMR chemical shifts and residual dipolar couplings

29 September 2017

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Mapping allostery through the covariance analysis of NMR chemical shifts

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Hyperpolarization-activated cyclic nucleotide-modulated 'HCN' channels confer regular and faster rhythmicity to beating mouse embryonic stem cells.

29 September 2017

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Gating of HCN channels by cyclic nucleotides: residue contacts that underlie ligand binding, selectivity, and efficacy

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Structural elements of instantaneous and slow gating in hyperpolarization-activated cyclic nucleotide-gated channels

29 September 2017

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29 September 2017

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Cyclic nucleotide-gated channels: shedding light on the opening of a channel pore

29 September 2017

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A doublet-separated sensitivity-enhanced HSQC for the determination of scalar and dipolar one-bond J-couplings

29 September 2017

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Structure and function of cyclic nucleotide-gated channels

29 September 2017

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Direct activation of cardiac pacemaker channels by intracellular cyclic AMP.

29 September 2017

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Architecture of the HCN selectivity filter and control of cation permeation

29 September 2017

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Resolution-adapted recombination of structural features significantly improves sampling in restraint-guided structure calculation

2 June 2018

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2 June 2018

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Evolutionary emergence of N-glycosylation as a variable promoter of HCN channel surface expression.

2 June 2018

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Alanine scanning of the S6 segment reveals a unique and cAMP-sensitive association between the pore and voltage-dependent opening in HCN channels

2 June 2018

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Molecular mechanism of cAMP modulation of HCN pacemaker channels.

2 June 2018

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21 January 2018

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Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states

21 January 2018

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Backbone dynamics and thermodynamics of Borrelia outer surface protein A.

21 January 2018

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Improved chemical shift based fragment selection for CS-Rosetta using Rosetta3 fragment picker

21 January 2018

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A conserved tripeptide in CNG and HCN channels regulates ligand gating by controlling C-terminal oligomerization.

21 January 2018

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Allo-network drugs: harnessing allostery in cellular networks

21 January 2018

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Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients

21 January 2018

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Label-free assay for thermodynamic analysis of protein-ligand interactions: a multivariate strategy for allosteric ligand screening

21 January 2018

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12 December 2020

Definition of an electrostatic relay switch critical for the cAMP-dependent activation of protein kinase A as revealed by the D170A mutant of RIalpha

1 reference

12 December 2020

Regulation of hyperpolarization-activated HCN channels by cAMP through a gating switch in binding domain symmetry

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12 December 2020

Entropy-driven cAMP-dependent Allosteric Control of Inhibitory Interactions in Exchange Proteins Directly Activated by cAMP

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12 December 2020

How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels

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12 December 2020

Evolution and structural diversification of hyperpolarization-activated cyclic nucleotide-gated channel genes

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12 December 2020

Identifiers

DOI

10.1074/JBC.M114.572164

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24878962%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24878962%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

2 references