Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy (Q27674646)

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Andrew G Jobson

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Joseph E Tropea

3

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Christopher R Self

4

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Guangtao Zhang

5

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Robert H Shoemaker

7

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David S Waugh

Journal of Structural Biology

8

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publication date

December 2011

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published in

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volume

176

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issue

3

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page(s)

292-301

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cites work

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Polyamines antagonize both the antileukemic activity and the reverse transcriptase stimulatory activity of 4,4'-diacetyldiphenylurea bis(guanylhydrazone) (DDUG)

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29 September 2017

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CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors

29 September 2017

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29 September 2017

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29 September 2017

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Activated checkpoint kinase 2 provides a survival signal for tumor cells

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

29 September 2017

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29 September 2017

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Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells

29 September 2017

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29 September 2017

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The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects

29 September 2017

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The structure-based design of ATP-site directed protein kinase inhibitors

29 September 2017

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Potential antitumor agents. 31. Quantitative structure-activity relationships for the antileukemic bis(guanylhydrazones)

29 September 2017

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[Model phases: probabilities and bias.

2 June 2018

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Activation segment exchange: a common mechanism of kinase autophosphorylation?

27 November 2018

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Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase.

27 November 2018

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Diacetyldiamidoximeester of pentamidine, a prodrug for treatment of protozoal diseases: synthesis, in vitro and in vivo biotransformation.

27 November 2018

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27 November 2018

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Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis

27 November 2018

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UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.

27 November 2018

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Chk2 molecular interaction map and rationale for Chk2 inhibitors

27 November 2018

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12 December 2020

Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation

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12 December 2020

Interactions between bis(guanylhydrazones) and polyamines in isolated mitochondria

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12 December 2020

Studies of N-hydroxy-N'-aminoguanidine derivatives by nitrogen-15 nuclear magnetic resonance spectroscopy and as ribonucleotide reductase inhibitors

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Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2

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12 December 2020