Structural basis for the autoinhibition of c-Abl tyrosine kinase (Q27640773)

8

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Klaus Scheffzek

4

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Oliver Hantschel

2

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Matthew Young

object named as

Matthew A Young

3

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author name string

Bhushan Nagar

1

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Darren Veach

5

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William Bornmann

6

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Bayard Clarkson

Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

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publication date

21 March 2003

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language of work or name

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112

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issue

6

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page(s)

859-71

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cites work

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An intramolecular SH3-domain interaction regulates c-Abl activity

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c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines

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Mutational analysis of the regulatory function of the c-Abl Src homology 3 domain

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential

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Direct Determination of Changes of Interdomain Orientation on Ligation: Use of the Orientational Dependence of15N NMR Relaxation in Abl SH(32)†

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Mobilization of the A-kinase N-myristate through an isoform-specific intermolecular switch

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Oncogenic activation of c-ABL by mutation within its last exon.

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A myristoyl/phosphotyrosine switch regulates c-Abl

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The conformational plasticity of protein kinases

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

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Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors

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Modular peptide recognition domains in eukaryotic signaling

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En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase

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7 January 2021

Intramolecular interactions of the regulatory domains of the Bcr-Abl kinase reveal a novel control mechanism

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AMoRe: an automated package for molecular replacement

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Processing of X-ray diffraction data collected in oscillation mode

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Autoinhibition of c-Abl

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Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid

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Disabling Abl-perspectives on Abl kinase regulation and cancer therapeutics

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Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

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7 January 2021

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

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Structure-function relationships in Src family and related protein tyrosine kinases

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Cellular functions regulated by Src family kinases

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Cycling, stressed-out and nervous: cellular functions of c-Abl

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The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions

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7 January 2021

Inhibition of c-Abl tyrosine kinase activity by filamentous actin

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Crystal structures of c-Src reveal features of its autoinhibitory mechanism

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7 January 2021

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

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Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation

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