Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair (Q27657670)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19804755%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair (English)

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9 February 2020

3

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Hiroshi Iwasaki

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John A. Tainer

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9 February 2020

R Scott Williams

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author name string

Gerald E Dodson

2

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Yoshiki Yamada

4

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Jessica S Williams

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Grant Guenther

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Scott Classen

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J N Mark Glover

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Paul Russell

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9 February 2020

language of work or name

English

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publication date

1 October 2009

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9 February 2020

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9 February 2020

volume

139

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issue

1

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page(s)

87-99

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Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

9 February 2020

cites work

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Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain

20 March 2017

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Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

20 March 2017

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Human CtIP promotes DNA end resection

20 March 2017

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

20 March 2017

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

20 March 2017

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Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

20 March 2017

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Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair

20 March 2017

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ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization

20 March 2017

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Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2

20 March 2017

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The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

20 March 2017

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Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1

20 March 2017

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Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase

20 March 2017

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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

20 March 2017

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The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

20 March 2017

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Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

20 March 2017

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Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex

20 March 2017

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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

20 March 2017

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BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

20 March 2017

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MDC1 is required for the intra-S-phase DNA damage checkpoint

20 March 2017

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MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

20 March 2017

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Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

20 March 2017

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7 April 2017

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29 September 2017

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Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

29 September 2017

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Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.

29 September 2017

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Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

29 September 2017

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Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination

29 September 2017

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Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

29 September 2017

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gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

29 September 2017

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RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability

29 September 2017

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Endonucleolytic processing of covalent protein-linked DNA double-strand breaks

29 September 2017

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Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

29 September 2017

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ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

29 September 2017

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The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase

29 September 2017

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Isolation and characterization of novel xrs2 mutations in Saccharomyces cerevisiae

29 September 2017

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Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.

29 September 2017

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Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes

29 September 2017

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An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

29 September 2017

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The FHA domain is a modular phosphopeptide recognition motif.

29 September 2017

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Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.

29 September 2017

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A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.

2 June 2018

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Nijmegen breakage syndrome (NBS) with neurological abnormalities and without chromosomal instability

2 June 2018

1 reference

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The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break

2 June 2018

1 reference

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Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein.

27 November 2018

1 reference

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10.1016/J.CELL.2009.07.033

27 November 2018

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9 February 2020

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9 February 2020

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